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首页> 外文期刊>Advances in enzyme regulation >Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid.
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Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid.

机译：参与溶血磷脂酸生产的生物合成途径的膜侧性。

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摘要

Lysophosphatidic acid (LPA) is a novel phospholipid mediator with diverse biological activities such as smooth muscle contraction, and proliferative effects or modifications of cytoskeleton. Activated blood platelets are the best identified source, explaining accumulation of LPA in serum upon blood coagulation. However, the metabolic pathways responsible for LPA synthesis are still poorly known. Using a model of human erythrocytes treated with the calcium ionophore A23187, we have shown that type II secretory phospholipase A2 (sPLA2) is able to produce LPA by hydrolyzing phosphatidic acid exposed on the cell surface after phospholipid scrambling. A similar mechanism does not appear to occur in platelets, where inhibitors of sPLA2 or genetic lack of the enzyme do not modify LPA production. However, this does not definitely eliminate the possibility that LPA is also produced in platelets in the external leaflet of the membrane by other phospholipases, which have to be better characterized.
机译：溶血磷脂酸（LPA）是一种新型的磷脂介质，具有多种生物学活性，例如平滑肌收缩，增殖作用或细胞骨架修饰。活化的血小板是最好的鉴定来源，这说明了血液凝固后血清中LPA的积累。然而，负责LPA合成的代谢途径仍然知之甚少。使用经过钙离子载体A23187处理的人类红细胞模型，我们已经显示II型分泌磷脂酶A2（sPLA2）能够通过水解磷脂扰乱后暴露在细胞表面的磷脂酸来产生LPA。血小板中似乎没有发生类似的机制，其中sPLA2抑制剂或酶的遗传缺乏不会改变LPA的产生。但是，这并不能完全消除其他磷脂酶在膜的外部小叶中的血小板中也产生LPA的可能性，这些磷脂酶必须加以更好的表征。

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