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首页> 外文期刊>Blood cells, molecules and diseases >Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular immune activation.
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Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular immune activation.

机译：在细胞免疫激活过程中，铁蛋白的H亚基和L亚基在骨髓巨噬细胞和赤道红细胞中的表达。

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BACKGROUND: The expression of the two types of ferritin subunits, the H-subunit and L-subunit, has been shown to be differentially regulated by cytokines. The primary aim of the present study was to quantitatively measure the expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron in patients with chronic T-helper cell type-1 immune stimulation. METHODS: The expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron was quantitatively evaluated by post-embedding immunolocalisation with immunogold transmission electron microscopy. RESULTS: The present study showed up-regulation of the H-subunit of ferritin in the bone marrow macrophage in patients with pronounced cellular immune activation (94.7+/-37.3 counts/mum(2); n=31 vs 72.4+/-34.0 counts/mum(2); n=13, p-value=0.037). CONCLUSION: This supports a possible role for H-subunit rich ferritins in the hypoferraemia of chronic disease.
机译：背景：已显示两种亚铁蛋白亚基（H亚基和L亚基）的表达受到细胞因子的差异调节。本研究的主要目的是定量测定慢性T辅助细胞1型免疫刺激患者骨髓巨噬细胞和红细胞中铁蛋白的H亚基和L亚基的表达。方法：采用免疫金透射电子显微镜对包埋后的免疫定位进行定量分析，以评估红蛋白在骨髓巨噬细胞和红细胞中H亚基和L亚基的表达。结果：本研究显示，在具有明显细胞免疫激活的患者中，骨髓巨噬细胞中铁蛋白的H亚基上调（94.7 +/- 37.3计数/妈妈（2）; n = 31 vs 72.4 +/- 34.0） counts / mum（2）; n = 13，p值= 0.037）。结论：这支持富含H亚基的铁蛋白在慢性疾病低铁血症中的可能作用。

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