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首页> 外文期刊>European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology >Plasma proteomic approach in patients with?heart failure: insights into pathogenesis of?disease progression and potential novel treatment targets
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Plasma proteomic approach in patients with?heart failure: insights into pathogenesis of?disease progression and potential novel treatment targets

机译：血浆蛋白质组学方法在患者？心力衰竭：患有症状的发病机制和潜在的新型治疗目标

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Abstract Aims To provide insights into pathogenesis of disease progression and potential novel treatment targets for patients with heart failure by investigation of the plasma proteome using network analysis. Methods and results The plasma proteome of 50 patients with heart failure who died or were rehospitalised were compared with 50 patients with heart failure, matched for age and sex, who did not have an event. Peptides were analysed on two‐dimensional liquid chromatography coupled to tandem mass spectrometry (2D LC ESI‐MS/MS) in high definition mode (HDMSE). We identified and quantified 3001 proteins, of which 51 were significantly up‐regulated and 46 down‐regulated with more than two‐fold expression changes in those who experienced death or rehospitalisation. Gene ontology enrichment analysis and protein–protein interaction networks of significant differentially expressed proteins discovered the central role of metabolic processes in clinical outcomes of patients with heart failure. The findings revealed that a cluster of proteins related to glutathione metabolism, arginine and proline metabolism, and pyruvate metabolism in the pathogenesis of poor outcome in patients with heart failure who died or were rehospitalised. Conclusions Our findings show that in patients with heart failure who died or were rehospitalised, the glutathione, arginine and proline, and pyruvate pathways were activated. These pathways might be potential targets for therapies to improve poor outcomes in patients with heart failure.
机译：摘要旨在通过使用网络分析研究血浆蛋白质蛋白质蛋白质蛋白质蛋白质患者提供疾病进展和潜在新型治疗靶标的洞察力。方法和结果50例心力衰竭患者的血浆蛋白质与死亡或被重新治疗的患者进行比较，与50例心力衰竭患者，与年龄和性别相匹配，没有活动。在高清晰度模式（HDMSE）中偶联至串联质谱（2DLCESI-MS / MS）的二维液相色谱上分析肽。我们鉴定和定量3001种蛋白质，其中51个显着上调，46个下调，在经历死亡或再生的那些人中有超过两倍的表达变化。基因本体富集分析和蛋白质 - 蛋白质相互作用网络的显着差异表达蛋白质发现代谢过程在心力衰竭患者临床结果中的核心作用。结果表明，与谷胱甘肽代谢，精氨酸和脯氨酸代谢，精氨酸和脯氨酸代谢相关的蛋白质，以及患者患者患者的患者的发病机制，患者死亡或被再婚的患者的发病机制。结论我们的研究结果表明，在患有死亡或再生的心力衰竭的患者中，激活谷胱甘肽，精氨酸和脯氨酸和丙酮酸途径。这些途径可能是治疗疗法的潜在目标，以改善心力衰竭患者患者的差异。

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