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首页> 外文期刊>European journal of drug metabolism and pharmacokinetics >Pharmacokinetics of Active Ingredients of Salvia miltiorrhiza and Carthamus tinctorius in Compatibility in Normal and Cerebral Ischemia Rats: A Comparative Study
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Pharmacokinetics of Active Ingredients of Salvia miltiorrhiza and Carthamus tinctorius in Compatibility in Normal and Cerebral Ischemia Rats: A Comparative Study

机译：丹参的活性成分药代动力学和脑缺血大鼠兼容性的丹参和迦太基菌群：比较研究

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Background and Objective Dan-Hong injection, which comprises extracts of Salvia miltiorrhiza and Carthamus tinctorius, promotes blood circulation and reduces blood stasis. Combination of S. miltiorrhiza and C. tinctorius is more effective in treating cerebral ischemia than S. miltiorrhiza alone. This study aimed to examine the pharmacokinetic characteristics of four active ingredients of S. miltiorrhiza and C. tinctorius, namely danshensu (DSS), hydroxysafflor yellow A (HSYA), and salvianolic acid A (SAA) and B (SAB) in normal and cerebral ischemia rats. Methods Normal and cerebral ischemia rats were injected via the tail vein with each active ingredient, and blood was collected through the jaw vein at different time points. The plasma concentration of the compatibility group was analyzed by high-performance liquid chromatography, and pharmacokinetic parameters were determined using Pharmacokinetic Kinetica 4.4 software. Results The pharmacokinetics of the four active ingredients in the normal and cerebral ischemia rats were consistent with a two-compartment model. The area under the concentration-time curve was higher in normal rats than in cerebral ischemia rats, with a highly significant difference for SAA (P < 0.01). Clearance rates were lower in normal rats than in cerebral ischemia rats, with DSS showing the most significant difference (P < 0.01). Furthermore, there were significant differences between normal and cerebral ischemia rats in the distribution phase-elimination half life for DSS, SAA, and HSYA, as well as in the apparent volume of distribution for the central compartment for DSS and HSYA (P < 0.01). The plasma concentrations of the four active ingredients were higher in normal rats than in cerebral ischemia rats. Conclusion Cerebral ischemia rats showed higher drug clearance rates and longer retention times than normal rats, which may be due to destruction of the blood-brain barrier during cerebral ischemia-reperfusion. The four active ingredients likely integrated and interacted with each other to affect target sites in the brain to protect against cerebral ischemic injury.
机译：背景和客观丹宏注射液，包括丹参和迦太基毒素的提取物，促进血液循环并减少血液瘀滞。 S. Miltiorrhiza和C.Tictizius的组合更有效地对待脑缺血而不是S. Miltiorrhiza。该研究旨在研究正常和脑中丹参（DSS），即丹参（DSS），丹参（DSS），羟基烷烃黄色A（HSYA）和SALVIANOLIC酸A（SAA）和B（SAB）的四种活性成分的药代动力学特征缺血大鼠。方法通过尾静脉注射正常和脑缺血大鼠，每种活性成分通过爪静脉注射血液，在不同的时间点通过颌静脉收集。通过高效液相色谱分析相容性组的血浆浓度，并使用药代动力学性血管内4.4软件测定药代动力学参数。结果正常和脑缺血大鼠中四种活性成分的药代动力学与双隔室模型一致。浓度 - 时间曲线下的面积在正常大鼠中比在脑缺血大鼠中较高，对SAA具有非常显着的差异（P <0.01）。正常大鼠的间隙率低于脑缺血大鼠，DSS显示出最显着的差异（P <0.01）。此外，对于DSS，SAA和HSYA的分布相消除半衰期，正常和脑缺血大鼠之间存在显着差异，以及DSS和HSYA的中央室的表观分布量（P <0.01） 。在正常大鼠中，四种活性成分的血浆浓度高于脑缺血大鼠。结论脑缺血大鼠表现出较高的药物清除率和较长的保留次数比正常大鼠可能是由于脑缺血再灌注过程中血脑屏障的破坏。四种活性成分可能整合和相互作用，以影响大脑中的靶位点，以防止脑缺血性损伤。

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