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首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Stem cell niche: Dynamic neighbor of stem cells
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Stem cell niche: Dynamic neighbor of stem cells

机译：干细胞Niche：干细胞的动态邻居

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摘要

Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a large number of soluble signaling factors and various biochemical and biophysical cues (such as oxygen tension, flow, and shear and pore size). Stem cells have the potential to be a powerful tool in regenerative medicine due to their self-renewal property and immense differentiation potential. Recent progresses in in vitro culture conditions of embryonic stem cells, adult stem cells and induced pluripotent stem cells have enabled the researchers to investigate and understand the role of the microenvironment in stem cell properties. The engineered artificial stem cell niche has led to a better execution of stem cells in regenerative medicine. Here we elucidate the key components of stem cell niche and their role in niche engineering and stem cell therapeutics.
机译：干细胞Niche是干细胞周围的一种专用和动态的微环境，其在保持干细胞的茎秆性能方面发挥着关键作用。多年来，研究活动的进步已经揭示了干细胞利基的各种重要方面，包括细胞 - 细胞相互作用，细胞 - 细胞间基质相互作用，大量可溶信号传导因子和各种生物化学和生物物理提示（如氧气张力，流动和剪切和孔径）。由于其自我更新性能和巨大的分化潜力，干细胞具有在再生药物中的强大工具。最近在体外培养条件的胚胎干细胞，成人干细胞和诱导多能干细胞的进展使研究人员能够研究和理解微环境在干细胞性质中的作用。工程化人造干细胞Niche导致更好地在再生医学中执行干细胞。在这里，我们阐明干细胞利基的关键组分及其在利基工程和干细胞治疗中的作用。

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