• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunology Letters >Immunological considerations underlying heat shock protein-mediated cancer vaccine strategies
【24h】

Immunological considerations underlying heat shock protein-mediated cancer vaccine strategies

机译：热休克蛋白介导的免疫考虑因素介导的癌症疫苗策略

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The success of active immunotherapies in the prevention of many infectious diseases over the course of over 200 years has lead scientists to wonder if the same principles could be applied to cancer. Antigen-specific active immunotherapies for the treatment of cancer have been researched for over two decades, however, the overwhelming majority of these studies have failed to stimulate robust clinical responses. It is clear that current active immunotherapy research should incorporate methods to increase the immunostimulatory capacity of these therapies. To directly address this need, we propose the addition of the immunostimulatory heat shock proteins (HSPs) to active immunotherapeutic strategies to augment their efficacy. Heat shock proteins are a family of highly conserved intracellular chaperone proteins, and are the most abundant family proteins inside cells. This ubiquity, and their robust immunostimulatory capacity, points to their importance in regulation of intracellular processes and, therefore, indicators of loss of cellular integrity if found extracellularly. Thus, we emphasize the importance of taking into consideration the location of vaccine-derived HSP/tumor-antigen complexes when designing active immunotheraputic strategies.
机译：活跃免疫治疗在预防200多年的历程中预防许多传染病的成功使科学家们想知道相同的原则是否可以应用于癌症。对癌症治疗的抗原特异性活性免疫检查已被研究超过二十年，然而，这些研究的绝大多数未能刺激稳健的临床反应。很明显，目前的活性免疫疗法研究应包括增加这些疗法的免疫刺激能力的方法。为了直接解决这种需求，我们提出将免疫刺激热休克蛋白（HSP）添加到活性免疫治疗策略中，以增加它们的功效。热休克蛋白是一种高度保守的细胞内伴侣蛋白的家庭，是细胞内最丰富的家族蛋白质。这种难以置信的和它们的鲁棒免疫刺激能力，指向细胞内方法的调节的重要性，因此如果发现细胞外，细胞完整性的指标。因此，我们强调了在设计活性免疫调节策略时考虑疫苗衍生的HSP /肿瘤抗原复合物的位置的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号