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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Regulatory T cells in cancer: where are we now?
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Regulatory T cells in cancer: where are we now?

机译：癌症中调节性T细胞：我们现在在哪里？

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Summary There have been substantial strides forward in our understanding of the contribution of regulatory T (Treg) cells to cancer immunosuppression. In this issue, we present a series of papers highlighting emerging themes on this topic relevant not only to our understanding of the fundamental biology of tumour immunosuppression but also to the design of new immunotherapeutic approaches. The substantially shared biology of CD 4 + conventional T (Tconv) and Treg cells necessitates a detailed understanding of the potentially opposing functional consequences that immunotherapies will have on Treg and Tconv cells, a prominent example being the potential for Treg‐mediated hyperprogressive disease following anti‐ PD ‐1 therapy. Such understanding will aid patient stratification and the rational design of combination therapies. It is also becoming clear, however, that Treg cells within tumours exhibit distinct biological features to both Tconv cells and Treg cells in other tissues. These distinct features provide the opportunity for development of targeted immunotherapies with greater efficacy and reduced potential for inducing systemic toxicity.
机译：发明内容我们对调节性T（Treg）细胞对癌症免疫抑制的贡献，有很大的努力。在这个问题中，我们提出了一系列论文，突出了本主题的新兴主题，不仅与我们对肿瘤免疫抑制基本生物学的理解，而且还要展开新的免疫治疗方法的设计。 CD 4 +常规T（TCONV）和Treg细胞的基本上共同的生物学需要详细了解免疫治疗对Treg和TconV细胞的可能相反的功能后果，突出的例子是抗议后的Treg介导的超出疾病的可能性。 - PD -1疗法。这种理解将有助于患者分层和组合疗法的合理设计。然而，它也很明显，肿瘤内的Treg细胞表现出不同的生物学特征，在其他组织中表现出TCONV细胞和Treg细胞。这些独特的特征提供了具有较高疗效和诱导全身毒性的疗效和降低潜力的靶标免疫疗法的机会。

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