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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >CD8 α α ? ? conventional dendritic cells control V β β T‐cell immunity in response to Staphylococcus aureus Staphylococcus aureus infection in mice
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CD8 α α ? ? conventional dendritic cells control V β β T‐cell immunity in response to Staphylococcus aureus Staphylococcus aureus infection in mice

机译：CD8αα？ 还 常规树突细胞对小鼠金黄色葡萄球菌葡萄球菌感染的响应蛋白的树突细胞免疫力

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Abstract Dendritic cells (DCs) are potent immune cells that control innate and adaptive immune responses. Previous studies have shown that the DCs are required for protection against Staphylococcus aureus infection. However, the role of conventional DC (cDC) subsets during S.?aureus infection in vivo has not been well investigated. In this study, we examined the function of spleen DC subsets in the activation of immunity against S.?aureus infection. C57BL/6 mice were infected intravenously with S.?aureus and DC and T‐cell activation were analyzed in vivo . We found that the spleen CD8 α ? cDCs phagocytosed S.?aureus more efficiently than type‐1 conventional DCs (cDC1s) did. Moreover, the CD8 α ? cDCs contributed to the production of pro‐inflammatory cytokines in response to S.?aureus infection , whereas the cDC1s did not. In addition, infection with S.?aureus promoted an increase in the number of V β T cells. The CD4 + and CD8 + V β T cells up‐regulated the production of interferon‐ γ (IFN‐ γ ) and interleukin‐17 (IL‐17) in response to S.?aureus infection. Importantly, the induction of IFN‐ γ and IL‐17 production in CD4 + and CD8 + V β T cells was mediated by S.?aureus ‐stimulated CD8 α ? cDCs, whereas cDC1s failed to promote IFN‐ γ and IL‐17 production in the cells. Therefore, these data suggested that the spleen CD8 α ? cDCs are the main DC subsets for induction of S.?aureus superantigen‐specific immunity.
机译：摘要树突细胞（DCS）是有效的免疫细胞，可控制先天性和适应性免疫反应。以前的研究表明，DCS需要防止金黄色葡萄球菌感染。然而，常规DC（CDC）亚群在体内S.Aureus感染期间的作用尚未得到很好的研究。在这项研究中，我们研究了脾脏DC子集在对S.Aureus感染激活免疫激活中的功能。将C57BL / 6小鼠静脉内与S.AUREUS感染，并在体内分析DC和T细胞活化。我们发现脾脏CD8α？ CDCS吞噬S.?URUSUS比1型常规DC（CDC1S）更有效。而且，CD8α？ CDCS响应于S.?Ureus感染而导致促炎细胞因子的产生，而CDC1也没有。此外，对S. aureus的感染促进了VβT细胞数量的增加。 CD4 +和CD8 +VβT细胞上调了干扰素-γ（IFN-γ）和白细胞介素-17（IL-17）的产生响应于S.Aureus感染。重要的是，CD4 +和CD8 + VβT细胞IFN-γ和IL-17产生的诱导由S.AUREUS-CD8α介导？ CDC，而CDC1s未能在细胞中促进IFN-γ和IL-17产生。因此，这些数据表明脾脏CD8α？ CDC是诱导S.Aureus Superigen特异性免疫的主要DC子集。

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