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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >1,25-dihydroxyvitamin D-3-induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells
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1,25-dihydroxyvitamin D-3-induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells

机译：1,25-二羟基素D-3诱导的树突细胞通过增加调节淋巴细胞的比例和减少T辅助型1和17型细胞来抑制实验性自身免疫性脑炎。

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Dendritic cells (DCs), a bridge for innate and adaptive immune responses, play a key role in the development of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Administration of tolerogenic DCs has been used as an immunotherapy in autoimmune diseases. Deficiency of vitamin D is an environmental risk factor of MS. In this study, we induced tolerogenic DCs by 1,25-dihydroxyvitamin D-3 and transferred the tolerogenic DCs (VD3-DCs) into EAE mice by adoptive transfer. We found that VD3-DCs inhibited the infiltrations of T helper type 1 (Th1) and Th17 cells into spinal cord and increased the proportions of regulatory T cells (CD4(+) CD25(+) Foxp3(+)), CD4(+) IL-10(+) T cells and regulatory B cells (CD19(+) CD5(+) CD1d(+)) in peripheral immune organs, which resulted in attenuated EAE. However, the proportions of T helper type 1 (Th1) and Th17 cells in spleen and lymph nodes and the levels of pro-inflammatory cytokines and IgG in serum also increased after transfer of VD3-DCs. We conclude that transfer of VD3-DCs suppressed EAE by increasing proportions of regulatory T cells, CD4(+) IL-10(+) T cells and regulatory B cells in spleen and reducing infiltration of Th1 and Th17 cells into spinal cord, which suggests a possible immunotherapy method using VD3-DCs in MS.
机译：树突状细胞（DCS），用于先天和适应性免疫反应的桥梁，在多发性硬化症（MS）和实验性自身免疫脑脊髓炎（EAE）的发展中起关键作用，是MS的动物模型。耐受性DCS的施用已被用作自身免疫疾病的免疫疗法。维生素D的缺乏是MS的环境风险因素。在本研究中，我们通过Pay采用转移诱导1,25-二羟基维生素D-3的耐含可DC，并将耐受性DC（VD3-DCS）转移到EAE小鼠中。我们发现VD3-DCS抑制T辅助型1（TH1）和TH17细胞的渗透到脊髓，并增加了调节T细胞的比例（CD4（+）CD25（+）Foxp3（+）），CD4（+） IL-10（+）T细胞和调节B细胞（CD19（+）CD5（+）CD1D（+））在外围免疫器官中，导致衰减EAE。然而，在转移VD3-DC的转移后，脾脏和淋巴结中的T辅助型1（TH1）和Th17细胞和血清中的促炎细胞因子和IgG的水平也增加。我们得出结论，通过增加调节性T细胞，CD4（+）IL-10（+）T细胞和调节B细胞在脾脏中的比例并将TH1和TH17细胞的渗透降至脊髓，转移VD3-DCS抑制EAE抑制了EAE。 MS中使用VD3-DCS的可能免疫疗法方法。

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