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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >The biology of natural killer cells during sepsis
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The biology of natural killer cells during sepsis

机译：败血症期间天然杀伤细胞的生物学

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Natural killer (NK) cells are large granular lymphocytes largely recognized for their importance in tumour surveillance and the host response to viral infections. However, as the major innate lymphocyte population, NK cells also coordinate early responses to bacterial infections by amplifying the antimicrobial functions of myeloid cells, especially macrophages, by production of interferon-gamma (IFN-gamma). Alternatively, excessive NK cell activation and IFN-gamma production can amplify the systemic inflammatory response during sepsis resulting in increased physiological dysfunction and organ injury. Our understanding of NK cell biology during bacterial infections and sepsis is mostly derived from studies performed in mice. Human studies have demonstrated a correlation between altered NK cell functions and outcomes during sepsis. However, mechanistic understanding of NK cell function during human sepsis is limited. In this review, we will review the current understanding of NK cell biology during sepsis and discuss the challenges associated with modulating NK cell function during sepsis for therapeutic benefit.
机译：天然杀手（NK）细胞大量粒状淋巴细胞，主要是在肿瘤监测和宿主对病毒感染的重要性方面认识到它们。然而，作为主要的先天淋巴细胞群，NK细胞还通过扩增骨髓细胞，尤其是巨噬细胞的抗微生物功能，通过产生干扰素-γ（IFN-Gamma）来协调对细菌感染的早期反应。或者，过量的NK细胞活化和IFN-Gamma产量可以扩增败血症期间的全身炎症反应，导致生理功能障碍和器官损伤增加。我们对细菌感染和败血症期间对NK细胞生物学的理解大多来自小鼠中进行的研究。人类研究表明，在败血症期间改变的NK细胞功能和结果之间的相关性。然而，在人败血症期间对NK细胞功能的机械理解理解有限。在本综述中，我们将在败血症期间审查目前对NK细胞生物学的了解，并讨论了在败血症期间调节NK细胞功能的挑战进行治疗益处。

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