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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Differences in activation and tissue homing markers of natural killer cell subsets during acute dengue infection
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Differences in activation and tissue homing markers of natural killer cell subsets during acute dengue infection

机译：急性登革热期间天然杀伤细胞亚群激活和组织归巢标志物的差异

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Summary Dengue virus (DENV) infection is considered one of the most important mosquito‐borne diseases. It causes a spectrum of illness that could be due to qualitative and/or quantitative difference(s) of the natural killer (NK) cell responses during acute DENV infection. This view prompted us to perform a detailed phenotypic comparative characterization of NK cell subsets from DENV‐infected patients with dengue fever (DF), patients with dengue haemorrhagic fever (DHF) and healthy controls. The activation/differentiation molecules, CD69 and CD57 and a variety of tissue homing molecules were analysed on the CD56 hi CD16 ? and CD56 lo CD16 + NK cells. Although there was no increase in the frequency of the total NK cells during DENV infection compared with the healthy individuals, there was a significant increase in the frequency of the CD56 hi CD16 ? subset and the frequency of CD69 expression by both NK cell subsets during the febrile phase of infection. We also found an increase in the frequencies of cells expressing CD69 and CD57 in the CD56 lo CD16 + subset compared with those in the CD56 hi CD16 ? subset. Moreover, although the CD56 lo CD16 + subset contained a high frequency of cells expressing skin‐homing markers, the CD56 hi CD16 ? subset contained a high frequency of cells expressing bone marrow and lymph node trafficking markers. Interestingly, no differences of these NK cell subsets were noted in samples from patients with DF versus those with DHF. These findings suggest that activation and differentiation and the patterns of tissue homing molecules of the two major NK cell subsets are different and that these might play a critical role in the immune response against acute DENV infection.
机译：总结登革热病毒（Denv）感染被认为是最重要的蚊子疾病之一。它会导致急性杀伤（NK）细胞反应的定性和/或定量差异的疾病，这可能是由于在急性Denv感染期间的定性和/或定量差异。这种观点促使我们对Denv-Cerved患者的登革热（DF）患者进行Denv感染患者进行详细的表型比较表征，登革热病（DHF）和健康对照。在CD56 Hi CD16上分析活化/分化分子，CD69和CD57和各种组织归巢分子？和CD56 LO CD16 + NK细胞。虽然与健康个体相比，在DenV感染期间，NK细胞总频率没有增加，但CD56 HI CD16的频率显着增加？在感染的发热期期间NK细胞亚群的CD69表达的子集和频率。我们还发现在CD56 LO CD16 +子集中表达CD69和CD57的细胞频率的增加与CD56 HI CD16中的CD56 +子集中观相比？子集。此外，尽管CD56 LO CD16 +子集含有高频率的表达皮肤归巢标记的细胞，但CD56 HI CD16？子集含有高频率的表达骨髓和淋巴结贩运标志物。有趣的是，来自DF与DHF的DF患者的样本中没有对这些NK细胞亚群的差异。这些发现表明，两个主要NK细胞亚群的激活和分化和组织归巢分子的模式不同，这些结果不同，这些结果可能在免疫反应中对抗急性Denv感染的影响。

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