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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Origins of natural killer cell memory: special creation or adaptive evolution
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Origins of natural killer cell memory: special creation or adaptive evolution

机译：自然杀手单元格记忆的起源：特殊创作或自适应演变

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摘要

The few initial formative studies describing non-specific and apparently spontaneous activity of natural killer (NK) cells have since multiplied into thousands of scientific reports defining their unique capacities and means of regulation. Characterization of the array of receptors that govern NK cell education and activation revealed an unexpected relationship with the major histocompatibility molecules that NK cells originally became well known for ignoring. Proceeding true to form, NK cells continue to up-end archetypal understanding of their ever-expanding capabilities. Discovery that the NK cell repertoire is extremely diverse and can be reshaped by particular viruses into unique subsets of adaptive NK cells challenges, or at least broadens, the definition of immunological memory. This review provides an overview of studies identifying adaptive NK cells, addressing the origins of NK cell memory and introducing the heretical concept of NK cells with extensive antigenic specificity. Whether these newly apparent properties reflect adaptive utilization of known NK cell attributes and receptors or a specially creative allocation from an undefined receptor array remains to be fully determined.
机译：少数初始形成研究，描述了自然杀伤（NK）细胞的非特异性和明显的自发性活性，因为乘以数以千计的科学报告，定义了它们独特的能力和调节手段。治理NK细胞教育和激活的受体阵列的表征揭示了与NK细胞最初被忽略众所周知的主要组织相容性的意外关系。继续表格，NK细胞继续上终原型的初始化了解其无法扩大的能力。发现NK Cell Repertoire非常多样化，并且可以通过特定病毒重塑成自适应NK细胞挑战的独特子集，或者至少扩大免疫记忆的定义。本综述概述了识别适应性NK细胞的研究概述，解决了NK细胞记忆的起源，并引入了具有广泛的抗原特异性的NK细胞的遗迹概念。这些新明显的特性是否反映了已知的NK小区属性和受体的自适应利用，或者来自未定义的受体阵列的特殊创造性分配仍然是待完全确定的。

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