Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects

Hu Chao; Miao Jia; Shu Shiqing; Wang Ying; Zhu Xiaohong; Luo Zhu

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Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects

机译：新型外列药物的药代动力学，药效学和安全性通过在健康的中国受试者中通过计量吸入器递送了通过计量吸入器

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摘要

Background: BDP/FF/GB pMDI is a novel triple fixed-dose combination of extra-fine inhalation aerosol beclomethasone dipropionate (BDP)/formoterol fumarate (FF)/glycopyrronium bromide (GB). Limited data on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of BDP/FF/GB fixed-dose combination in healthy subjects was available.

机译：背景：BDP / FF / GB PMDI是一种新型三重固定剂量的超细吸入气溶胶替代塞洛醇二丙酸酯（BDP）/ Formoterol富马酸盐（FF）/果肉溴化物（GB）。可获得有限的药代动力学（PK）和药效学（PD）的BDP / FF / GB固定剂量组合在健康受试者中的有限数据。

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来源
《European journal of pharmaceutical sciences》 |2020年第1期|共8页
作者
Hu Chao; Miao Jia; Shu Shiqing; Wang Ying; Zhu Xiaohong; Luo Zhu;
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作者单位

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

Sichuan Univ West China Hosp Inst Drug Clin Trials GCP Ctr Chengdu 610041 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Extrafine BDP/FF/GB combination; Pharmacokinetics; Pharmacodynamics;

机译：Extrafine BDP / FF / GB组合;药代动力学;药效学;

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1. Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects [J] . Hu Chao, Miao Jia, Shu Shiqing, European journal of pharmaceutical sciences . 2020,第1期

机译：新型外列药物的药代动力学，药效学和安全性通过在健康的中国受试者中通过计量吸入器递送了通过计量吸入器
2. BECLOMETHASONE DIPROPIONATE PHARMACOKINETICS DELIVERED BY BREATH-ACTUATED INHALER AND METERED-DOSE INHALER IN HEALTHY SUBJECTS [J] . Ratner P., Gillespie M., Small C. Annals of allergy, asthma, and immunology . 2016,第5Suppla1期

机译：呼吸道吸入吸入器和定量剂量吸入器在健康受试者体内释放的倍他米松双丙酸酯药代动力学
3. Comparison of the systemic pharmacodynamic effects and pharmacokinetics of salmeterol delivered by CFC propellant and non-CFC propellant metered dose inhalers in healthy subjects. [J] . Kempsford R, Handel M, Mehta R, Respiratory medicine . 2005,第Suppla1期

机译：CFC推进剂和非CFC推进剂计量吸入器对沙美特罗的全身药效学作用和药代动力学的比较。
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Healthy Subjects and Patients with Chronic Liver Disease [D] . NOMOTO, Maiko 2019

机译：阿法曲巴帕在健康受试者和慢性肝病患者中的药代动力学/药效学分析
6. Pharmacokinetics of Salmeterol and Fluticasone Propionate Delivered in Combination via Easyhaler and Diskus Dry Powder Inhalers in Healthy Subjects [O] . Merja Kirjavainen, Leena Mattila, Mikko Vahteristo, -1

机译：经由Easyhaler和Diskus干粉吸入器组合输送的沙美特罗和丙酸氟替卡松在健康受试者中的药代动力学
7. Comparison of the systemic pharmacodynamic effects and pharmacokinetics of salmeterol delivered by CFC propellant and non-CFC propellant metered dose inhalers in healthy subjects [O] . Kempsford Rodger, Handel Malcolm, Mehta Rashmi, 2005

机译：CFC推进剂和非CFC推进剂计量吸入器对沙美特罗的全身药效学作用和药代动力学的比较

Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects

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