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首页> 外文期刊>European journal of pharmaceutical sciences >Oral delivery of non-viral nucleic acid-based therapeutics - do we have the guts for this?
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Oral delivery of non-viral nucleic acid-based therapeutics - do we have the guts for this?

机译：口服递送非病毒核酸的治疗方法 - 我们是否有肠道？

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摘要

Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and poor cellular permeation. The delivery of nucleic acids, in particular by the oral route, remains a major hurdle. This review will focus on the barriers to the oral delivery of nucleic acids and the strategies, in particular formulation strategies, which have been developed to overcome these barriers. Due to their very low oral bioavailability, the most obvious and most investigated biomedical applications for their oral delivery are related to the local treatment of inflammatory bowel diseases and colorectal cancers. Preclinical data but not yet clinical studies support the potential use of the oral route for the local delivery of formulated nucleic acid-based drugs.
机译：具有RNA和基于PDNA的药物的基因治疗受酶促稳定性差和细胞渗透差的限制。 核酸递送，特别是口腔途径仍然是一个主要障碍。 该审查将专注于核酸口服递送的障碍和策略，特别是制定的制定策略，这些策略是为了克服这些障碍而制定的。 由于它们非常低的口服生物利用度，最明显和最明显的，其口腔递送的生物医学应用涉及炎症性肠病和结肠直肠癌的局部治疗。 临床节数据但尚未临床研究支持口腔途径的潜在用途，用于局部递送配制的核酸基药物。

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