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首页> 外文期刊>European journal of preventive cardiology >Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies
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Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies

机译：内皮一氧化氮合酶基因多态性的关联及冠状动脉疾病风险：132个病例对照研究的系统综述与荟萃分析

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The roles of endothelial nitric oxide synthase gene polymorphisms in coronary artery disease have been intensively analyzed, with inconsistent results. Therefore, we performed this study to better assess the relationship between endothelial nitric oxide synthase genetic variations and the risk of coronary artery disease. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to evaluate associations between endothelial nitric oxide synthase polymorphisms and coronary artery disease. A total of 132 genetic association studies were finally included. Significant associations with the risk of coronary artery disease were detected for the rs891512, rs1799983, rs2070744, rs11771443 and rs869109213 polymorphisms. Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians. When we stratified data based on type of disease, we found that the rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly correlated with the risk of myocardial infarction or acute coronary syndrome in certain genetic models. In conclusion, our findings indicate that the rs891512, rs1799983, rs2070744, rs11771443 and rs869109213 polymorphisms may serve as genetic biomarkers of coronary artery disease.
机译：在冠状动脉疾病中，内皮一氧化氮合酶基因多态性的作用被密集分析，结果不一致。因此，我们进行了该研究以更好地评估内皮一氧化氮合酶遗传变异与冠状动脉疾病风险的关系。在PubMed，Medline，Embase和Science Web中搜索合格的研究。利用95％置信区间的差异比率评估内皮型一氧化氮合酶多态性和冠状动脉疾病之间的关联。最终包括132项遗传关联研究。为RS891512，RS17999983，RS2070744，RS11771443和RS869109213的多态性检测到具有冠状动脉疾病风险的重要组态。进一步的亚组根据参与者的种族分析，揭示了RS1799983和RS2070744的多态性与白种人和亚洲人的冠状动脉疾病的风险显着相关，而RS869109213多态性只与高加索人冠状动脉疾病的风险有关。当我们基于疾病类型分层数据时，我们发现RS1799983，RS2070744和RS869109213多态性与某些遗传模型中心肌梗死或急性冠状动脉综合征的风险显着相关。总之，我们的研究结果表明，RS891512，RS17999983，RS2070744，RS11771443和RS869109213多态性可能是冠状动脉疾病的遗传生物标志物。

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