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首页> 外文期刊>European journal of preventive cardiology >Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm
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Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm

机译：腹主动脉瘤新型诊断和预后生物标志物的鉴定

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Aims: Abdominal aortic aneurysm is a life-threatening condition due to the risk of aneurysm growth and rupture. There are no approved diagnostic or prognostic biomarkers for abdominal aortic aneurysm. We aimed to identify diagnostic and prognostic biomarkers for abdominal aortic aneurysm and to investigate their relationship with abdominal aortic aneurysm diameter and growth. Methods: In this case-control study, patients were included from an abdominal aortic aneurysm screening study on men aged >= 65 years. Of 24,589 examined men, 415 had abdominal aortic aneurysm, out of whom 134 consented to participate in the present study. One hundred and thirty-six screened men with aortic diameter <30 mm, matched for comorbidities and time of sampling were included as non-abdominal aortic aneurysm patients. Ninety-one cardiovascular specific proteins in plasma samples were measured by the Proseek Multiplex CVD III96x96 panel. Results: After Bonferroni correction, plasma levels of 21 proteins associated with proteolysis, oxidative-stress, lipid metabolism, and inflammation were significantly increased, whereas levels of paraoxonase 3, associated with high-density lipoprotein metabolism, were decreased in abdominal aortic aneurysm patients. Combination of growth/differentiation factor 15 and cystatin B had the best ability to discriminate abdominal aortic aneurysm from non-abdominal aortic aneurysm (area under the curve, 0.76; sensitivity, 80% and specificity, 52%). Myeloperoxidase showed the best prognostic value (area under the curve, 0.71; sensitivity, 80% and specificity, 59%) and higher baseline levels of myeloperoxidase were significantly associated with faster abdominal aortic aneurysm growth compared with lower levels, independent of baseline diameter. Conclusions: We have identified multiple proteins associated with abdominal aortic aneurysm diameter and growth with a potential to become novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm.
机译：目的：由于动脉瘤生长和破裂的风险，腹主动脉瘤是一种危及生命的病症。腹主动脉瘤没有批准的诊断或预后生物标志物。我们旨在鉴定腹主动脉瘤的诊断和预后生物标志物，并调查与腹主动脉瘤直径和生长的关系。方法：在这种情况下，患者患有腹膜动脉瘤筛查研究中的患者，= 65岁。 24,589名检查男性，415名患有腹主动脉瘤，其中134人同意参加本研究。作为非腹主动脉瘤患者，包含一百三十六个具有主动脉直径<30毫米的筛选男性，符合用于血管性动脉瘤和抽样的时间。血浆样品中的九十一体心血管特异性蛋白质由Vareek Multiplex CVD III96X96面板测量。结果：在Bonferroni校正后，与蛋白水解，氧化应激，脂质代谢和炎症相关的21种蛋白质的血浆水平显着增加，而腹主动脉瘤患者患有高密度脂蛋白代谢的亚氧酶3水平。生长/分化因子15和胱抑素B的组合具有鉴别非腹主动脉瘤（曲线下的面积，0.76;敏感性，80％和特异性，52％）的最佳能力。髓过氧化物酶显示出最佳预后值（曲线下的面积，0.71;敏感性，80％和特异性，59％）和较高的基线水平与腹主动脉瘤生长更快，与较低的水平无关，与基线直径无关。结论：我们已经确定了与腹主动脉瘤直径和生长相关的多种蛋白质，其潜力成为腹主动脉瘤的新诊断和预后生物标志物。

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