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首页> 外文期刊>European journal of preventive cardiology >Estimation of cardiovascular risk based on total cholesterol versus total cholesterol/high-density lipoprotein within different ethnic groups: The HELIUS study
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Estimation of cardiovascular risk based on total cholesterol versus total cholesterol/high-density lipoprotein within different ethnic groups: The HELIUS study

机译：基于总胆固醇的心血管风险估计与不同族群中总胆固醇/高密度脂蛋白的心血管风险：Helius研究

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Aims European guidelines recommend estimating cardiovascular disease risk using the Systematic COronary Risk Evaluation (SCORE) algorithm. Two versions of SCORE are available: one based on the total cholesterol/high-density lipoprotein cholesterol ratio, and one based on total cholesterol alone. Cardiovascular risk classification between the two algorithms may differ, particularly among ethnic minority groups with a lipid profile different from the ethnic majority groups among whom the SCORE algorithms were validated. Thus in this study we determined whether discrepancies in cardiovascular risk classification between the two SCORE algorithms are more common in ethnic minority groups relative to the Dutch. Methods Using HELIUS study data (Amsterdam, The Netherlands), we obtained data from 7572 participants without self-reported prior cardiovascular disease of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan ethnic origin. For both SCORE algorithms, cardiovascular risk was estimated and used to categorise participants as low ( = 10%) risk. Odds of differential cardiovascular risk classification were determined by logistic regression analyses. Results The percentage of participants classified differently between the algorithms ranged from 8.7% to 12.4% among ethnic minority men versus 11.4% among Dutch men, and from 1.9% to 5.5% among ethnic minority women versus 6.2% among Dutch women. Relative to the Dutch, only Turkish and Moroccan women showed significantly different (lower) odds of differential cardiovascular risk classification. Conclusion We found no indication that discrepancies in cardiovascular risk classification between the two SCORE algorithms are consistently more common in ethnic minority groups than among ethnic majority groups.
机译：目的欧洲指南建议使用系统冠军风险评估（得分）算法估算心血管疾病风险。可提供两种版本的分数：一个基于总胆固醇/高密度脂蛋白胆固醇比，一个基于单独的总胆固醇。两种算法之间的心血管风险分类可能不同，特别是少数民族群体中，少数群体中具有不同于验证得分算法的少数群体的脂质剖面。因此，在这项研究中，我们确定了两次得分算法之间的心血管风险分类的差异是否在少数群体中相对于荷兰语更常见。方法采用Helius研究数据（阿姆斯特丹，荷兰），我们从7572名参与者获得数据，没有自我报告的荷兰语，南亚苏里南，非洲苏里南人，加纳，土耳其和摩洛哥族裔血管疾病。对于评分算法，估计心血管风险并用于将参与者分类为低（= 10％）风险。差异心血管风险分类的几率由逻辑回归分析确定。结果少数民族男性少数民族男性与11.4％之间分类的参与者不同的参与者百分比范围为8.7％至12.4％，少数民族妇女少数民族妇女的1.9％〜5.5％。相对于荷兰人，只有土耳其和摩洛哥妇女才显示出显着不同的（较低）差异心血管风险分类的可能性。结论我们发现，两次评分算法之间的心血管风险分类中的差异差异在少数群体中持续差异，而不是民族群体。

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