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首页> 外文期刊>European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology >Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task
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Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task

机译：精神分裂症和双相情感障碍患者的功能磁共振谱：在工作记忆任务期间前刺刺伤皮层中的谷氨酸动力学

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The glutamate system is implicated in the pathophysiology of schizophrenia and mood disorders. Using functional magnetic resonance spectroscopy (H-1-fMRS), it is possible to monitor glutamate dynamically in activated brain areas and may give a closer estimate of glutamatergic neurotransmission than standard magnetic resonance spectroscopy. 14 patients with schizophrenia, 15 patients with bipolar disorder II (BPII) and 14 healthy volunteers underwent a 15 min N-back task in a 48s block design during H-1-fMRS acquisition. Data from the first, second and third 16s group of 8 spectra for each block were analysed to measure levels of glutamate and Glx (glutamate + glutamine), scaled to total creatine (TCr), across averaged 0-back and 2-back conditions. A 6 x 3 repeated-measures analysis of variance (rmANOVA) demonstrated a significant main effect of time for Glx/TCr (P = 0.022). There was a significant increase in Glu/TCr (P = 0.004) and Glx/TCr (P 0.001) between the final spectra of the 0-back and first spectra of the 2-back condition in the healthy control group only. 2 x 2 rmANOVA revealed a significant time by group interaction for Glx/TCr (P = 0.019) across the 0-back condition, with levels reducing in healthy controls and increasing in the schizophrenia group. While healthy volunteers showed significant increases in glutamatergic measures between task conditions, the lack of such a response in patients with schizophrenia and BPII may reflect deficits in glutamatergic neurotransmission. Abnormal increases during periods of relatively low executive load, with-out the same dynamic modulation as healthy volunteers with increasing task difficulty, further suggests underlying abnormalities of glutamatergic neurotransmission in schizophrenia. (c) 2018 Elsevier B.V. and ECNP. All rights reserved.
机译：谷氨酸系统涉及精神分裂症和情绪障碍的病理生理学。使用功能性磁共振光谱（H-1-FMRS），可以在活性脑区域动态监测谷氨酸，并且可以仔细估计谷氨酸神经递质而不是标准磁共振光谱。 14例精神分裂症患者，15例双相障碍患者II（BPII）和14名健康志愿者在H-1-FMRS采集期间在48S块设计中进行了15分钟的N背部任务。从第一，第二和第三16S组的数据的数据进行分析，以测量谷氨酸和Glx（谷氨酸+谷氨酰胺）的水平，缩小到总肌酸（TCR），平均为0返回和2背部条件。 6 x 3反复测量方差分析（RMANOVA）证明了GLX / TCR时间的显着主要效果（P = 0.022）。仅在健康对照组的2-背部条件的0背部和第一光谱的最终光谱之间存在显着增加的Glu / TCR（p <0.004）和GLX / TCR（P <0.001）。 2×2 rmanova在0背条件下通过GLX / TCR的相互作用揭示了大量的时间，水平降低了健康对照和精神分裂症组中的增加。虽然健康的志愿者表现出任务条件之间的谷氨酸杆菌措施的显着增加，但患有精神分裂症和BPII患者的这种反应可能反映谷氨酸宫神经递质的缺陷。相对低的执行载荷期间的异常增加，随着工作难度的增加，具有与健康志愿者相同的动态调制，进一步表明精神分裂症中谷氨酸神经传递的根本异常。 （c）2018 Elsevier B.V.和ECNP。版权所有。

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