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首页> 外文期刊>Experimental and therapeutic medicine >Values of detection of NF-B activation level combined with IL-6 and TNF- levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma
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Values of detection of NF-B activation level combined with IL-6 and TNF- levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma

机译：在严重多发性创伤患者的多器官功能障碍综合征预测中，对外周中性粒细胞的NF-B活化水平的检测值与外周中性粒细胞中的患者

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The aim of this study was to analyze the dynamic changes and predictive values of nuclear factor-B (NF-B) combined with interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) in peripheral blood in multiple organ dysfunction syndrome (MODS) in patients with severe multiple trauma. Seventy patients diagnosed with severe multiple trauma in Emergency Department of Sichuan Provincial People's Hospital (Chengdu, China) from April 2014 to April 2016 were selected and retrospectively analyzed. The patients enrolled were divided into the MODS group (n=25) and the non-MODS group (n=45). The injury severity scores (ISSs), acute physiology and chronic health evaluation II (APACHE II) scores, NF-B, IL-6 and TNF- levels in patients were detected at different time points (12, 24 and 48 h after admission), the changes in different indexes and the areas under the receiver operating characteristic (ROC) curve (AUC) were analyzed. The predictive values of different detection methods in MODS patients were discussed and compared. The ISS, APACHE II score, NF-B, IL-6 and TNF- levels in the MODS group at admission and 24 and 48 h after admission were higher than those in the non-MODS group (P0.05). Those indexes in the deceased patients at 12, 24 and 48 h after admission were higher than those in survivors (P0.05). The ISS, APACHE II score, NF-B, IL-6 and TNF- levels were not the risk factors of MODS in patients with severe multiple trauma (P0.05). AUCs of ISS 22 points and APACHE II score 14 points in predicting MODS were lower than that of combined detection of NF-B 1.20. In conclusion, the combined detection of NF-B, IL-6 and TNF- in peripheral blood of patients with acute multiple trauma is more helpful to predict the occurrence of MODS, which has a certain guiding significance for the prognosis of patients with MODS.
机译：本研究的目的是分析核因子-B（NF-B）与白细胞介素-6（IL-6）和肿瘤坏死因子 - （TNF-）在多个器官功能障碍中的肿瘤坏死因子（TNF-）的动态变化和预测值严重的多发性创伤患者综合征（MODS）。选择七十名患者在2014年4月至2016年4月的四川省人民医院（成都，中国）急急诊患者中诊断出严重创伤，并回顾性分析。注册的患者分为MODS组​​（n = 25）和非MODS组​​（n = 45）。在不同的时间点（入院后12,24和48小时）检测患者伤害严重程度（ISSS），急性生理学和慢性健康评估II（APACHE II）评分，NF-B，IL-6和TNF-水平） ，分析了不同索引和接收器操作特征（ROC）曲线（AUC）下的区域的变化。讨论和比较了MODS患者不同检测方法的预测值。在入院后ModS组的ISS，Apache II得分，NF-B，IL-6和TNF-水平高于非MODS组​​（P <0.05）中的24和48小时。入院后12,24和48小时的死者患者的指标高于幸存者（P <0.05）。 ISS，Apache II得分，NF-B，IL-6和TNF-水平不是严重的多个创伤患者中MOD的危险因素（P＆GT; 0.05）。 ISS＆GT的AUC; 22点和Apache II得分＆GT;预测MOD的14个点低于NF-B＆GT的组合检测.1.20。总之，NF-B，IL-6和TNF-在急性多个创伤患者的外周血中的结合检测更有助于预测MODS的发生，这对MODS患者的预后具有一定的指导意义。

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