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首页> 外文期刊>Experimental and therapeutic medicine >An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
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An implantable electrical stimulator used for peripheral nerve rehabilitation in rats

机译：一种用于大鼠周围神经康复的可植入电刺激器

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This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model.
机译：该研究评估了使用坐骨神经损伤动物模型的可植入电刺激器，以及道德，电生理学和组织学评估。在研究中使用了四十Sprague-Dawley大鼠，并用微容器夹具粉碎右侧坐骨神经。在20只大鼠（植入组）中植入电刺激器，而剩余的20只大鼠被分配给对照组。手术后的三个和六周，与对照组相比，植入族神经功能指数（SFI）和运动神经传导速度（MCV）在植入组中显着较高（P <0.05）。组织学分析，使用苏木精和曙红（H＆E）染色，显示出典型的病理萎缩，以及被压碎的神经的评估显示对照组中的远端轴突分解。这些结果表明，可植入的电刺激器是有效的，并且适用于Sprague-Dawley大鼠模型中的植入。

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