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首页> 外文期刊>Experimental and therapeutic medicine >Clinical efficacy of aspirin combined with clopidogrel in treating cerebral infarction and its effect on serum hs-CRP, sICAM-1 and TNF-alpha
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Clinical efficacy of aspirin combined with clopidogrel in treating cerebral infarction and its effect on serum hs-CRP, sICAM-1 and TNF-alpha

机译：阿司匹林联合氯吡格雷治疗脑梗死的临床疗效及其对血清HS-CRP，SICAM-1和TNF-α的影响

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Clinical efficacy of aspirin combined with clopidogrel in treating cerebral infarction and its influence on serum high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and tumor necrosis factor-alpha (TNF-alpha) were explored. Ninety patients with acute cerebral infarction treated in Yidu Central Hospital of Weifang were analyzed, and those treated with aspirin alone were group A (n=40) and those treated with aspirin and clopidogrel were group B (n=50) according to the different treatment plans. The NIHSS score, total effective rate and incidence rate of adverse reactions after treatment and admission were compared between the two groups. The expression level of hs-CRP was detected by enzyme-linked immunosorbent assay, and the expression levels of sICAM-1 and TNF-alpha were analyzed by radioimmunoassay before treatment and three weeks after surgery, respectively, and they were analyzed and compared. After treatment, the total effective rate of patients in group B was significantly higher than that of group A (P<0.05). The general clinical baseline information, NIHSS score, and the expression levels of hs-CRP, sICAM-1, and TNF-alpha of patients in group B were significantly improved after treatment compared with those before treatment (P<0.05), and the NIHSS score and the expression levels of serum hs-CRP, sICAM-1, and TNF-alpha of those in group B were significantly lower than those in group A (P<0.05). Combination therapy of aspirin and clopidogrel can improve cerebral infarction effectively, and inhibit the expression levels of hs-CRP, sICAM-1 and TNF-alpha more effectively than aspirin alone.
机译：阿司匹林与氯吡格雷联合治疗脑梗死的临床疗效及其对血清高敏性C反应蛋白（HS-CRP）的影响，可溶性细胞间粘附分子-1（SICAM-1）和肿瘤坏死因子-α（TNF-α ）被探索了。分析了在潍坊市中央医院治疗的九十患有急性脑梗死，单独用阿司匹林处理的那些（N = 40），根据不同的处理，用阿司匹林和氯吡格雷处理的那些是B（n = 50）计划。在两组之间比较了NIHSS评分，治疗和入场后不良反应的总有效率和发病率。通过酶联免疫吸附测定检测HS-CRP的表达水平，并通过放射免疫测定在治疗前和手术后三周分析SICAM-1和TNF-α的表达水平，并分析并比较它们。治疗后，B组患者的总有效率明显高于A组（P <0.05）。在治疗比较后，术后临床基线信息，NIHS评分和B组患者的表达水平和B组B组患者的表达水平（P <0.05）和NIHSS（P <0.05）和NIHS B组血清HS-CRP，SICAM-1和TNF-α的得分和表达水平明显低于A组（P <0.05）。阿司匹林和氯吡格雷的组合治疗可以有效地改善脑梗塞，并更有效地抑制HS-CRP，SICAM-1和TNF-α的表达水平，而不是单独的阿司匹林。

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