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首页> 外文期刊>Experimental and therapeutic medicine >Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling
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Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling

机译：Cox-2抑制剂Parecoxib对脊柱ERK信号传导抑制外科疼痛的镇痛作用

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Cyclooxygenase (COX)-2 inhibitors are widely used for postoperative pain control in clinical practice. However, it is unknown whether spinal sensitization is involved in the analgesic effects of COX-2 inhibitors on surgical pain. Extracellular signal-regulated kinase (ERK) in the spinal cord is implicated in various types of pain, including surgical pain. The present study investigated the role of spinal ERK signaling in the analgesic effect of the COX-2 inhibitor parecoxib on surgical pain. Surgical pain was produced in rats by surgical incision of the hind paw. Phosphorylated (p)-ERK1/2 expression was determined by immunohistochemistry. Pain hypersensitivity was evaluated by measuring the paw withdrawal threshold using the von Frey test. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. However, post-treatment with parecoxib produced minimal analgesic effects. Parecoxib inhibited the increase in spinal p-ERK expression following surgical incision. The present study thus suggests that the COX-2 inhibitor parecoxib exerts its analgesic effect on surgical pain through the inhibition of neuronal ERK activation in the spinal cord. COX-2 inhibitor delivery prior to surgery has more potent analgesic effects, suggesting the advantage of preventive analgesia for post-operative pain control.
机译：环氧氧基酶（COX）-2抑制剂广泛用于临床实践中的术后疼痛控制。然而，尚不清楚脊柱敏化是否参与了COX-2抑制剂对外科疼痛的镇痛作用。脊髓中的细胞外信号调节激酶（ERK）涉及各种类型的疼痛，包括手术疼痛。本研究研究了脊柱ERK信号传导在COX-2抑制剂Parecoxib对外科疼痛的镇痛作用中的作用。通过后爪手术切口，在大鼠中产生外科疼痛。通过免疫组织化学测定磷酸化（P）-ERK1 / 2表达。通过使用von Frey测试测量爪子取出阈值来评估疼痛超敏反应。通过腹膜内注射切开后，选择性Cox-2抑制剂Parecoxib在切口后20分钟递送。用Parecoxib进行预处理明显减毒切口诱导的疼痛超敏反应。然而，用Parecoxib进行后处理产生了最小的镇痛作用。 Parecoxib抑制手术切口后脊柱P-ERK表达的增加。因此，本研究表明，Cox-2抑制剂Parecoxib通过抑制脊髓中神经元ERK活化来施加其对手术疼痛的镇痛作用。在手术前的COX-2抑制剂递送具有更多有效的镇痛作用，表明预防性镇痛对术后疼痛控制的优势。

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