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首页> 外文期刊>Experimental and therapeutic medicine >Predicative values of C-reactive protein for the therapeutic effects of ulinastatin combined with somatostatin in severe acute pancreatitis and for the severity of gastrointestinal failure
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Predicative values of C-reactive protein for the therapeutic effects of ulinastatin combined with somatostatin in severe acute pancreatitis and for the severity of gastrointestinal failure

机译：C-反应蛋白的预测值，乌氏素素治疗生长抑素在严重急性胰腺炎中的治疗作用及胃肠衰竭严重程度

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摘要

Severe acute pancreatitis (SAP) is a serious systemic disease with high mortality. Ulinastatin is a drug widely used for patients with SAP and multiple organ failure syndrome. The present study aimed to investigate the capacity of the serum C-reactive protein (CRP) levels to predict the therapeutic effects of ulinastatin combined with somatostatin as well as determine the severity of SAP. SAP patients were treated with ulinastatin combined with somatostatin and serum CRP levels were measured. The computed tomography severity index (CTSI), acute physiology and chronic health evaluation II (APACHE II) and gastrointestinal failure scores were used to determine the therapeutic effects. All patients were assigned to the effective group and the ineffective group. Receiver operating characteristic curve analysis was performed to determine the sensitivity and specificity of CRP levels in predicting the severity of SAP and patient prognosis. Logistic regression analysis was adopted to investigate the factors influencing the therapeutic effects. Prior to and after treatment, serum CRP levels in patients of the effective and ineffective groups were significantly different. After treatment, serum CRP levels in patients of the effective group exhibited a more obvious reduction. The sensitivity and specificity of serum CRP levels in predicting the therapeutic effects of ulinastatin combined with somatostatin in SAP patients upon hospital admission were 0.813 and 0.934, respectively. Serum CRP levels were positively correlated with APACHE II, CTSI and gastrointestinal failure scores of SAP patients. The logistic regression demonstrated that serum albumin, creatinine and CRP levels on admission were factors influencing the therapeutic effects of ulinastatin combined with somatostatin in SAP patients. These results indicate that serum CRP levels may have a predictive value regarding the therapeutic effects of ulinastatin combined with somatostatin and are an indicator of the severity of gastrointestinal failure in SAP.
机译：严重的急性胰腺炎（SAP）是一种严重的全身疾病，具有高死亡率。乌纳替肽是一种广泛用于SAP患者和多器官失效综合征的药物。本研究旨在探讨血清C-反应蛋白（CRP）水平以预测乌司汀与生长抑制菌素的治疗作用以及确定SAP的严重程度的能力。用乌炔菌素治疗SAP患者，结合生长抑素，测量血清CRP水平。使用计算的断层扫描严重性指数（CTSI），急性生理学和慢性健康评估II（Apache II）和胃肠失败分数来确定治疗效果。将所有患者分配给有效群体和无效组。进行接收器操作特征曲线分析以确定CRP水平的灵敏度和特异性预测SAP和患者预后的严重程度。采用逻辑回归分析来研究影响治疗效果的因素。在治疗之前和之后，有效和无效患者的血清CRP水平显着不同。治疗后，有效组患者的血清CRP水平表现出更明显的减少。血清CRP水平预测乌司汀在医院入院后SAP患者中生长抑制素联合生长抑素的治疗效果的敏感性和特异性分别为0.813和0.934。血清CRP水平与Apache II，CTSI和胃肠道失败评分呈正相关。逻辑回归表明，入院的血清白蛋白，肌酐和CRP水平是影响乌氏菌素与Sap患者生长抑素联合的因素的因素。这些结果表明，血清CRP水平可能具有关于乌司汀与生长抑制素的治疗作用的预测值，并且是SAP中胃肠失败的严重程度的指标。

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