Effect of ouabain on myocardial remodeling in rats

Ren Yanping; Zhang Mingjuan; Zhang Ting; Huang Ruowen

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Effect of ouabain on myocardial remodeling in rats

机译：Ouabain对大鼠心肌重塑的影响

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The aim of this study was to investigate the effect of ouabain (EO) on myocardial remodeling. Twenty-two adult male Sprague-Dawley rats were randomly divided into two groups: the rats in the EO group (n=12) were intraperitoneally injected with EO daily and those in the control group (n=10) were injected with physiological saline daily. After 8 weeks the rats were sacrificed. The ultrastructural changes in the myocardium were observed. The expression levels of voltage-gated potassium channel 4.2 (K(v)4.2) were detected by real-time quantitative reverse transcription-polymerase chain reaction. The effects of EO on the myocardial action potential and transient potassium efflux (I-to) were measured by patch clamping. The systolic blood pressure (SBP) of 10 of the 12 rats in the EO group, designated as the EO-sensitive (OS) rats, began to increase from the fifth week of treatment and was significantly higher compared with that of the control group 6 weeks later (P 0.05) were designated as EO-resistant (OR) rats. Pathological ultrastructural changes were significant in the apical mid-myocardium of the OS rats. No significant differences in K(v)4.2 expression were observed among the OS, OR and control rats. The patch clamp results revealed that EO prolongs the action potential duration, reduces I-to and triggers the electrical remodeling of the myocardium. EO induces a blood pressure increase and triggers structural and electrical remodeling.

机译：本研究的目的是探讨Ouabain（EO）对心肌重塑的影响。将22只成年雄性Sprague-Dawley大鼠随机分为两组：EO组（n = 12）中的大鼠每天用EO腹膜内注射，每天用生理盐水注射对照组（n = 10）。 8周后，牺牲了大鼠。观察到心肌的超微结构变化。通过实时定量逆转录 - 聚合酶链反应检测电压门控钾通道4.2（k（v）4.2）的表达水平。通过贴片夹紧测量EO对心肌动作电位和瞬时钾生效（I-To）的影响。作为EO组的12只大鼠中的10只大鼠的收缩压（SBP）开始从治疗的第五周开始增加，与对照组6的相比显着提高几周后（P 0.05）被指定为抗eo抗性（或）大鼠。病理超微结构的变化在OS大鼠的顶端心肌中显着。在OS或对照大鼠中没有观察到K（v）4.2表达的显着差异。膜片钳位结果显示EO延长动作电位持续时间，降低I-to并触发心肌的电气重塑。 EO诱导血压增加并触发结构和电气重塑。

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《Experimental and therapeutic medicine》 |2013年第1期|共6页
作者
Ren Yanping; Zhang Mingjuan; Zhang Ting; Huang Ruowen;
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作者单位

Xi An Jiao Tong Univ Coll Med Affiliated Hosp 1 Geriatr Cardiovasc Dept Xian 710061 Shaanxi;

Xi An Jiao Tong Univ Coll Med Affiliated Hosp 2 Cardiovasc Dept Xian 710003 Shaanxi Peoples R;

Xi An Jiao Tong Univ Coll Med Affiliated Hosp 1 Geriatr Cardiovasc Dept Xian 710061 Shaanxi;

Xi An Jiao Tong Univ Coll Med Affiliated Hosp 1 Geriatr Cardiovasc Dept Xian 710061 Shaanxi;

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正文语种 eng
中图分类治疗学;
关键词
ouabain; myocardic; remodeling;

机译：Ouabain;心肌;重塑;

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专利

1. Effect of ouabain on myocardial remodeling in rats [J] . Ren Yanping, Zhang Mingjuan, Zhang Ting, Experimental and therapeutic medicine . 2013,第1期

机译：Ouabain对大鼠心肌重塑的影响
2. Ouabain induces cardiac remodeling in rats independent of blood pressure [J] . Xing JIANG, Yan-ping REN, Zhuo-ren L(U) 中国药理学报：英文版 . 2007,第003期

机译：哇巴因诱导大鼠心脏重构，而与血压无关
3. The expression of transforming growth factor-β1 in myocardial tissue and concentration of serum B-type natriuretic peptide in myocardial remodeling of Sprague-Dawley rats treated with carvedilol [J] . R. Yi, G. Xiangyu, S. Min European review for medical and pharmacological sciences. . 2017,第21期

机译：用Carvedilol治疗Sprague-Dawley大鼠心肌复制血清B型利钠肽心肌组织和血清B型利钠肽浓度的表达
4. The Mechanical Research of Yuxingeng Fluid on Early Ventricular Remodeling in Wistar Rats with Acute Myocardial Infarction (AMI) [C] . Shi Dazhuo, Dong Guqju, Liu Jiangang National Young Scientist's Symposium on Integrative Medicine . 2002

机译：宇星庚液对Wistar大鼠急性心肌梗死早期心室重构的力学研究
5. The effects of resistance versus endurance exercise on cardiac function, myocardial remodeling and hormone response in post-myocardial infarction rats. [D] . Wason, Emily A. 2016

机译：抵抗力与耐力运动对心肌梗死后大鼠心功能，心肌重塑和激素反应的影响。
6. Effect of ouabain on myocardial remodeling in rats [O] . YANPING REN, MINGJUAN ZHANG, TING ZHANG, -1

机译：哇巴因对大鼠心肌重塑的影响
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Effect of ouabain on myocardial remodeling in rats

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