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首页> 外文期刊>Experimental and therapeutic medicine >Homocysteine, interleukin-10, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima-media thickness
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Homocysteine, interleukin-10, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima-media thickness

机译：同型半胱氨酸，白细胞蛋白-10和空腹血糖水平作为糖尿病的预后标志物，其与脑梗死复杂，与颈动脉内膜厚度相关

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摘要

Diabetes mellitus complicated with cerebral infarction (DMCI) has a high incidence and disability rate. Therefore, identification of biomarkers for the early prediction of the development and progression of cerebral infarction (CI) is of great significance for the prevention and treatment of this disease. The roles of serum homocysteine (Hey), interleukin-ip (IL-ip), and fasting blood glucose (FBG) in DMCI and their correlations with carotid intima-media thickness (CIMT) were explored. A total of 124 patients with DMCI (DMCI group) and 103 patients with diabetes mellitus (DM) (DM group) admitted to the People's Hospital of Liuhe District of Nanjing were enrolled in this study. A further 100 healthy controls undergoing physical examinations during the same period (HC group) were also enrolled. CIMT value was detected by carotid artery ultrasound. Hey and FBG levels were determined by a fully automatic biochemical analyzer. The IL-ip level was detected by enzyme-linked immunosorbent assay (ELISA). The levels of Hey, IL-lp, and FBG and the CIMT value in the DMCI and DM groups were significantly higher than those in the HC group (P<0.001). The levels and the value in the DMCI group were significantly higher than those in the DM group (P<0.001). Hey, IL.-1(3, and FBG levels were positively correlated with CIMT value (r=0.542, P<0.001; r=0.522, P<0.001; r=0.402, P<0.001). Receiver operating characteristic (ROC) curves showed that the sensitivity and specificity of
机译：糖尿病复杂的脑梗死（DMCI）具有高发病率和残疾率。因此，鉴定生物标志物的早期预测脑梗死的发育和进展（CI）对于预防和治疗这种疾病具有重要意义。探讨了血清同型半胱氨酸（γ），白细胞介素-IP（IL-IP）和空腹血糖（FBG）的作用及其与颈动脉内介质厚度（CIMT）的相关性及其相关性。在本研究中注册了总共124例DMCI（DMCI组）和103例糖尿病患者（DM）（DM）（DM）（DM集团）的患者，入学。还注册了在同一时期（HC组）中进行体检的另外100种健康对照。通过颈动脉超声检测CIMT值。嘿和FBG水平由全自动生化分析仪确定。通过酶联免疫吸附试验（ELISA）检测IL-IP水平。 γ，IL-LP和FBG的水平和DMCI和DM组中的CIMT值显着高于HC组中的水平（P <0.001）。 DMCI组的水平和值显着高于DM组（P <0.001）。嘿，IL.-1（3和FBG水平与CIMT值呈正相关（r = 0.542，p <0.001; r = 0.522，p <0.001; r = 0.402，p <0.001）。接收器操作特征（ROC）曲线表明敏感性和特异性

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