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首页> 外文期刊>Experimental and therapeutic medicine >Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease
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Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease

机译：冬虫夏草Sinensis抑制慢性阻塞性肺病大鼠的气道重塑

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摘要

Cordyceps sinensis is a traditional Chinese herbal medicine that has been used for centuries in Asia as a tonic to soothe the lung for the treatment of respiratory diseases. The aim of the present study was to determine the effects of C. sinensis on airway remodeling in chronic obstructive pulmonary disease (COPD) and investigate the underlying molecular mechanisms. Rats with COPD were orally administered C. sinensis at low, moderate or high doses (2.5, 5 or 7.5 g/kg/day, respectively) for 12 weeks. Airway tissue histopathology, lung inflammation and airway remodeling were evaluated. C. sinensis treatment significantly ameliorated airway wall thickening, involving collagen deposition, airway wall fibrosis, smooth muscle hypertrophy and epithelial hyperplasia in model rats with COPD. Additionally, C. sinensis administration in rats with COPD reduced inflammatory cell accumulation and decreased inflammatory cytokine production, including tumor necrosis factor-alpha, interleukin-8 and transforming growth factor (TGF)-beta 1 in bronchoalveolar lavage fluid. Meanwhile, the increased levels of alpha-smooth muscle actin and collagen I in the COPD group were also markedly decreased by C. sinensis treatment. Furthermore, compared with untreated rats with COPD, C. sinensis reduced the expression level of phosphorylated (p)-Smad2, p-Smad3, TGF-beta 1 and its receptors, with the concomitant increased expression of Smad7 in the lungs of rats with COPD. These results indicated that treatment with C. sinensis may be a useful approach for COPD therapy.
机译：冬虫夏草中药是一种传统的中草药，已在亚洲几个世纪作为滋补来抚慰肺部治疗呼吸系统疾病。本研究的目的是确定C. Sinensis对慢性阻塞性肺病（COPD）中的气道重塑的影响，并研究下面的分子机制。将具有COPD的大鼠在低，中等或高剂量（2.5,5或7.5g / kg /天）以低，中等或高剂量（分别为2.5,5或7.5g / kg /天）施用12周。评估呼吸道组织组织病理学，肺炎和气道重塑。 C. Sinensis治疗显着改善了气道壁增厚，涉及COPD模型大鼠的胶原沉积，气道壁纤维化，平滑肌肥大和上皮增生。此外，C.Inensis在具有COPD的大鼠中施用炎症细胞积累和降低炎症细胞因子产生，包括肿瘤坏死因子-α，白细胞介素-8和转化的支气管肺泡灌洗液中的生长因子（TGF）-Beta 1。同时，C.Sinensis治疗也显着降低了COPD组中的α-平滑肌肌动蛋白和胶原蛋白I的水平增加。此外，与COPD的未处理大鼠相比，C. Sinensis降低了磷酸化（P）-SmAd2，p-Smad3，TGF-β1及其受体的表达水平，随着Smad7在具有COPD的大鼠肺中的表达增加。这些结果表明，用C. sinensis治疗可能是COPD治疗的有用方法。

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    Yang Lei; Jiao Xingai; Wu Jinxiang; Zhao Jiping; Liu Tian; Xu Jianfeng; Ma Xiaohui; Cao Liuzao; Liu Lin; Liu Yahui; Chi Jingyu; Zou Minfang; Li Shuo; Xu Jiawei; Dong Liang;

  • 作者单位

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Prov Chest Hosp Dept TB Jinan 250013 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Qilu Hosp Dept Pulm Med 107 Wenhuaxi Rd Jinan 250012 Shandong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 治疗学;
  • 关键词

    Cordyceps sinensis; chronic obstructive pulmonary disease; airway inflammation; airway remodeling; transforming growth factor-beta 1/Smad signaling pathway;

    机译：冬虫夏草Sinensis;慢性阻塞性肺病;气道炎症;气道重塑;转化生长因子-β1/ Smad信号通路;

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