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首页> 外文期刊>Experimental Lung Research >Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat
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Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat

机译：再灌注后立即滴注水肿可改善缺血/再灌注诱导的大鼠移植肺的损伤

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Purpose: Lung ischemia-reperfusion injury (LIRI) after lung transplantation can lead to primary graft dysfunction. Budesonide can improve endothelial function to reduce lung injury. This study was aimed to examine the effects of budesonide on LIRI and potential mechanisms. Methods: Wistar rats were randomized and transplanted with syngeneic left lung or received the sham surgery. The recipients were instilled with saline or budesonide immediately after reperfusion. The mean arterial pressure (MAP), blood gas, and lung histology were analyzed. The ratios of wet to dry lung weights, the levels of total proteins, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, and IL-10, and neutrophil elastase in bronchoalveolar lavage fluid (BALF) were measured. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), and xanthine oxidase (XO) in the lung, and the levels of plasma lymphocyte function-associated antigen (LFA)-1 and P-selectinwere determined. Results: Comparedwith the saline group, treatment with budesonide significantly increased blood PaO2, but reduced PaCO2, and mitigated lung damages after reperfusion, the levels of BALF proteins, and the ratios ofwet to dry lung weights in rats. Furthermore, treatment with budesonide significantly decreased the levels of MDA, MPO, and XO in the lung and the levels of TNF-alpha, IL-1 beta, IL-6, and neutrophil elastase, but increased IL-10 in the BALF, accompanied by significantly reduced levels of serum P-selectin and LFA-1 in rats. Conclusions: Budesonide effectively mitigated LIRI and ameliorated the lung function by attenuating oxidative stress and inflammation following syngeneic lung transplantation.
机译：目的：肺移植后肺缺血再灌注损伤（LIRI）可导致原发性移植物功能障碍。预先提高内皮功能，以减少肺损伤。本研究旨在探讨预杉的影响对Liri和潜在机制。方法：Wistar大鼠随机随机移植，并用Syngeeneic左肺移植或接受假手术。再灌注后立即用盐水或水果苷滴注受体。分析了平均动脉压（MAP），血气和肺组织学。潮湿的干肺重量，总蛋白水平，肿瘤坏死因子（TNF） - 白细胞肺泡灌洗液中的中性粒细胞弹性蛋白酶和中性粒细胞弹性蛋白酶（BALF ）被测量。肺炎醛（MDA），髓氧化酶（MPO）和黄嘌呤氧化酶（XO）的水平，以及测定血浆淋巴细胞功能相关抗原（LFA）-1和P-SELETINWER的水平。结果：比较盐水组，用灌胃剂治疗显着增加血液PAO2，但减少了PACO2，再灌注后的缓解肺损伤，BALF蛋白水平，以及WET在大鼠中干肺重量的比例。此外，用培养酮烷治疗显着降低了肺中MDA，MPO和XO的水平和TNF-α，IL-1β，IL-6和中性粒细胞弹性蛋白酶的水平，但在BALF中增加了IL-10，伴随着通过大鼠LFA-1的显着降低的血清P-选择蛋白和LFA-1水平。结论：通过在红细胞移植后衰减氧化应激和炎症，有效减轻肺泡和改善肺功能。

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