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首页> 外文期刊>Experimental Brain Research >Microstimulation-induced inhibition of thalamic reticular nucleus in non-human primates
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Microstimulation-induced inhibition of thalamic reticular nucleus in non-human primates

机译：微氧化诱导的非人类原始植物中丘脑网状核的抑制

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The thalamic reticular nucleus (TRN) modulates activity in the thalamus and controls excitatory input from corticothalamic and thalamocortical glutamatergic projections. It is made up of GABAergic neurons which project topographically to the thalamus. The TRN also receives inhibitory projections from the globus pallidus and the substantia nigra pars reticulata. Photostimulation of the TRN results in local inhibition in rat slice preparations but the effects of local stimulation in vivo are not known. This study aimed to characterize stimulation-evoked responses in the TRN of non-human primates (NHPs). Microelectrodes were inserted into the TRN and neurons were stimulated at 5, 10, 15, and 20 mu A using 0.5s trains at 100Hz and the subsequent response was recorded from the same electrode. Stimulation in surrounding nuclei and the internal capsule was used for mapping the anatomical borders of the TRN. Stimulation as low as 10 mu A resulted in predominantly inhibition, recorded in both single units and background unit activity (BUA). The duration of inhibition (1-3s) increased with increasing stimulation amplitude and was significantly increased in BUA when single units were present. At 20 mu A of current, 93% of the single units (41/44) and 92% of BUA sites (67/73) were inhibited. Therefore, microstimulation of the NHP TRN with low currents results in current-dependent inhibition of single units and BUA. This finding may be useful to further aid in localization of deep thalamic and subthalamic nuclei during brain surgery.
机译：丘脑网状核（TRN）调节丘脑中的活性，并控制皮质母植物和肌淋巴质谷氨酸的兴奋性输入。它由巨大的新神经元组成，该神经元拓扑地突出到丘脑。该TRN还从Globus Pallidus和Impliaia nigra Pars Reticulata接收抑制突起。 TRN的光刺激导致大鼠切片制剂中的局部抑制，但局部刺激在体内的影响是未知的。该研究旨在表征在非人类原始化物（NHPS）中的刺激诱发的反应。将微电极插入Trn，在5,10,15和20μmA下刺激神经元，使用0.5s培训，在100Hz下，从同一电极记录后续响应。在周围细胞核中刺激和内囊泡用于映射TRN的解剖边界。刺激低至10μA导致主要抑制，以单位单位和背景单元活动（BUA）记录。抑制（1-3s）的持续时间随着刺激幅度的增加而增加，并且在存在单位单位时在BUA中显着增加。目前的20亩，抑制了93％的单位（41/44）和92％的Bua位点（67/73）。因此，具有低电流的NHP TRN的微刺激导致对单个单元和BUA的电流抑制。在脑手术期间，该发现可能有助于进一步辅助深层丘脑和次粒子核的定位。

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