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首页> 外文期刊>Experimental Brain Research >In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem
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In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem

机译：在Utero暴露于丙戊酸中，扰乱了对听觉脑干的下小粒子的中央核的上升突起

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摘要

Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans. Accordingly, in utero exposure to VPA is a validated and biologically relevant animal model of ASD. The majority of individuals with ASD exhibit some degree of auditory dysfunction, ranging from deafness to hypersensitivity. Animals exposed to VPA in utero have abnormal tonotopic maps and responses in the cerebral cortex and hyperactivation, hypoplasia, abnormal neuronal morphology and reduced calcium binding protein expression throughout the auditory brainstem nuclei. Further, our previous work suggests that GABAergic neuronal populations may be more severely impacted by in utero VPA exposure. However, the axonal projection patterns of brainstem nuclei to the inferior colliculus (IC) have not been investigated in VPA-exposed animals. Herein, we use stereotaxic injections of the retrograde tracer Fast Blue into the central nucleus of the IC (CNIC) and examine the proportions of retrogradely labeled neurons in the nuclei of the lateral lemniscus, superior olivary complex and cochlear nuclei. Our results indicate that not only are there fewer neurons in the auditory brainstem after VPA exposure, but also that fewer neurons are retrogradely labeled from the CNIC. Together, our results indicate that in utero VPA exposure may result in altered patterns of input to the auditory midbrain.
机译：抗癫痫丙戊酸（VPA）的产前暴露与人类自闭症谱系障碍（ASD）的风险增加有关。因此，在UTERO暴露于VPA中是ASD的验证和生物相关的动物模型。随着ASD的大多数人表现出一定程度的听觉功能障碍，从耳聋到超敏反应。暴露于UTETO中VPA的动物具有异常的脑皮层和脑皮质和多动，发育不全，异常神经元形态和在整个听觉脑干核中减少钙结合蛋白表达的反应。此外，我们以前的作品表明，在子宫VPA暴露中，Gabaigic神经元群可能会更严重地影响。然而，在VPA暴露的动物中尚未研究脑干核的脑干核的轴突投影模式。在此，我们使用逆行示踪剂的立体胶质喷射进入IC（CNIC）的中央核（CNIC），并在横向Lemniscus，优质寡核综合体和耳蜗核的核中检查逆行标记的神经元的比例。我们的结果表明，VPA暴露后，视听脑干中的神经元不仅有更少的神经元，而且还有更少的神经元从CNIC逆行标记。我们的结果表明，在子宫VPA暴露中可能导致对听觉中脑的输入模式改变。

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