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首页> 外文期刊>Experimental Neurology >Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections - Consequences on nociception, inflammatory and neuropathic pain in rats
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Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections - Consequences on nociception, inflammatory and neuropathic pain in rats

机译:慢病毒载体驱动抑制5-HT合成的B3防脊脊髓血管干燥奈诺奈奈酮突发 - 对大鼠伤害,炎症和神经病疼痛的影响

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摘要

Although it is well established that bulbo-spinal serotonergic projections contribute to pain control mechanisms, whether they exert anti-or pro-nociceptive modulations is still a matter of debate. In order to reappraise the role of 5-HT in descending controls, we used RNA interference to selectively inhibit 5-HT synthesis in B3 neurons and assess resulting changes in nociception.
机译:虽然很好的是,防风脊柱血管直酮能投射有助于疼痛控制机制,但它们是否施加抗或亲伤害调制仍然是争论的问题。 为了重新评估5-HT在下降控制中的作用,我们使用RNA干扰在B3神经元中选择性地抑制5-HT合成并评估导致伤害的变化。

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