...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Gerontology >Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus
【24h】

Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus

机译：长期跑步机锻炼通过恢复在老年人海马的瞬时脑缺血诱导的突触粘附分子1/2/3减少的突触粘附分子1/2/3来提高记忆障碍

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Exercise improves cognitive impairments induced by transient cerebral ischemia, and modulates synaptic adhesion molecules. In this study, we investigated effects of long-term treadmill exercise on cognitive impairments and its relation to changes of synaptic cell adhesion molecule (SynCAM) 1/2/3 in the hippocampus after 5?min of transient cerebral ischemia in aged gerbils. Animals were assigned to sedentary and exercised groups, given treadmill exercise for 4 consecutive weeks from 5?days after transient ischemia, and evaluated cognitive function through passive avoidance test and Morris water maze test. SynCAM 2 protein levels were determined in the hippocampus by western blot. In addition, neuronal and synaptic changes were examined by NeuN immunohistochemistry, and SynCAM 1/2/3 and MAP2 double immunofluorescence, respectively. We found that transient cerebral ischemia led to neuronal death in the CA1 area and dentate gyrus, and impaired -memory function; however, 4?weeks of treadmill exercise improved ischemia-induced memory impairment. In addition, SynCAM 1/2/3 and SynCAM 2 expression in the hippocampus was significantly decreased in the sedentary group after transient cerebral ischemia; however, SynCAM 1/2/3 expressionand and SynCAM 2 protein level was significantly increased in the ischemic group with exercise. These results suggest that long-term treadmill exercise improves memory impairment through the restoration of decreased SynCAM 1/2/3 expression in the hippocampus induced by transient cerebral ischemia in the aged gerbil. Highlights ? Memory was impaired following transient cerebral ischemia ? Long-term treadmill exercise improved ischemia-induced memory impairment. ? Transient cerebral ischemia induced neuronal loss in the CA1 area of the hippocampus. ? Transient cerebral ischemia induced SynCAM reduction in the all hippocampal subregions. ? Treadmill exercise restored ischemia-induced memory deficits by improving SynCAM
机译：摘要锻炼改善了瞬时脑缺血诱导的认知障碍，并调节突触粘附分子。在这项研究中，我们调查了长期跑步机运动对认知障碍的影响及其与海马中突触细胞粘附分子（Syncam）1 / 2/3变化的关系在老年人的脑内脑缺血后5〜min。将动物分配给久坐不动的和行使组，给予跑步机锻炼，连续4周从瞬时缺血后5周，并通过被动避免试验和莫里斯水迷宫测试评估了认知功能。 Syncam 2通过Western印迹在海马中测定了蛋白质水平。此外，通过Neun免疫组织化学检查神经元和突触变化，以及Syncam 1/2/3和Map2双免疫荧光。我们发现瞬时脑缺血导致CA1区域和牙齿的神经元死亡，并且损害 - 杂项功能;然而，4个？几周的跑步机练习改善缺血引起的记忆障碍。此外，在瞬时脑缺血后，海马中的同性恋1/2/3和Syncam 2在海马中的表达显着降低;然而，在缺血群体中，Syncam 1/2/3的表达和同步2蛋白质水平在运动中显着增加。这些结果表明，长期跑步机锻炼通过恢复在老年人的脑脊液中的瞬时脑缺血诱导的海马中减少的同步1/2/3表达来提高内存障碍。强调 ？瞬时脑缺血后记忆受到损害？长期跑步机练习改善缺血引起的记忆障碍。还瞬时脑缺血在海马CA1面积中诱导神经元损失。还瞬时脑缺血诱导所有海马次区域的同步减少。还跑步机锻炼通过改进Syncam来恢复缺血引起的内存缺陷

著录项

  • 来源
    《Experimental Gerontology》 |2018年第2018期|共8页
  • 作者

    Ji Hyeon Ahn; Joon Ha Park; Jinseu Park; Myoung Cheol Shin; Jun Hwi Cho; In Hye Kim; Jeong-Hwi Cho; Tae-Kyeong Lee; Jae-Chul Lee; Bich Na Shin; Young-Myeong Kim; Choong Hyun Lee; In Koo Hwang; Il Jun Kang; Bai Hui Chen; Bing Chun Yan; Young Joo Lee; Moo-Ho Won; Soo Young Choi;

  • 作者单位

    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology Hallym;

    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology Hallym;

    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology Hallym;

    Department of Emergency Medicine School of Medicine Kangwon National University;

    Department of Emergency Medicine School of Medicine Kangwon National University;

    Department of Neurobiology School of Medicine Kangwon National University;

    Department of Neurobiology School of Medicine Kangwon National University;

    Department of Neurobiology School of Medicine Kangwon National University;

    Department of Neurobiology School of Medicine Kangwon National University;

    Department of Physiology College of Medicine Hallym University;

    Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University;

    Department of Pharmacy College of Pharmacy Dankook University;

    Department of Anatomy and Cell Biology College of Veterinary Medicine Research Institute for;

    Department of Food Science and Nutrition Hallym University;

    Department of Histology and Embryology Institute of Neuroscience Wenzhou Medical University;

    Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and;

    Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University;

    Department of Neurobiology School of Medicine Kangwon National University;

    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology Hallym;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

    Aging; Cerebral ischemia; Learning and memory; Rehabilitation; Synaptic adhesion molecules; Treadmill exercise;

    机译：老化;脑缺血;学习和记忆;康复;突触粘附分子;跑步机运动;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号