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首页> 外文期刊>Experimental Gerontology >Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats
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Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats

机译：住房条件对雄性和雌性费斯344大鼠社会行为，神经疫苗标志物和催产素受体表达的影响

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摘要

Aging is associated with a substantial decline in social behavior, whereas positive social interaction can improve overall health in aged individuals. In laboratory rodents, manipulations of the social environment across the lifespan have been shown to affect social behavior. Therefore, we examined the effects of long-term (5-6 weeks) housing conditions (alone, with one adult, or with two adults) on social behavior and the expression of neuroinflammation-related genes as well as oxytocin receptor (OXTR) gene expression in brain areas associated with social behavior regulation in aged male and female Fischer (F) 344 rats. Single-housed males and females exhibited increased social investigation, relative to pair-housed rats (one aged and one adult). Triple-housed (one aged and two adults) aged males exhibited lower levels of social investigation, relative to triple-housed aged females. Aged females were more socially active that their male counterparts. Although social housing condition significantly affected social behavior in males, it had no impact on cytokine gene expression in the paraventricular nucleus of hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) or medial amygdala (MeA). However, in triple-housed aged females, who exhibited social behavior comparable to their single- and pair-housed counterparts, there was a significant increase in the expression of IL-1 beta and IL-6 mRNA in the MeA. No changes in cytokine gene expression were observed in the PVN or BNST, indicating that the increased expression of cytokines in the MeA was not a result of a generalized increase in neuroinflammation. Single-housed males and females exhibited elevated OXTR gene expression in the BNST. Taken together, these data indicate that manipulations of the social environment in late aging significantly influenced social interactions with a novel partner and gene expression in social behavior circuits and that these effects are sex-specific.
机译：老龄化与社会行为的大幅下降有关，而积极的社会互动可以改善老年人的整体健康。在实验室啮齿动物中，已经表明，在寿命周围的社会环境的操纵会影响社会行为。因此，我们研究了长期（5-6周）住房条件（单独，一个成人或两名成人）对社会行为以及神经炎症相关基因以及催产素受体（OXTR）基因的表达的影响与年龄和女性费舍（F）344大鼠社会行为调节相关的脑区的表达。单一住宅的男性和女性相对于配对的大鼠（一个老年人和一个成人）表现出社会调查增加。相对于三楼老年的女性，男性年龄龄的三屋（老年人和两名成人）表现出较低的社会调查。老年女性更具社会活跃，以至于他们的男性对应物。虽然社会住房条件在雄性中显着影响社会行为，但它对丘脑盆腔（PVN）的静脉内核（PVN），StriaSivalis（BNST）或内侧杏仁菌（MEA）的床核产生了对细胞因子基因表达的影响。然而，在三级老年的女性中，他表现出与其单一和配对的对应物相当的社会行为，在MEA中的IL-1β和IL-6 mRNA的表达显着增加。在PVN或BNST中没有观察到细胞因子基因表达的变化，表明MEA中细胞因子的表达增加不是神经炎症的广义增加的结果。单独的男性和女性在BNST中表现出升高的oxtr基因表达。总之，这些数据表明，社会环境在晚期时代的操纵显着影响了社会行为电路中的新型合作伙伴和基因表达的社会互动，这些影响是性别特异性。

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  • 来源
    《Experimental Gerontology》 |2019年第2019期|共10页
  • 作者

    Perkins Amy E.; Varlinskaya Elena I; Deak Terrence;

  • 作者单位

    SUNY Binghamton Binghamton Univ Dept Psychol Behav Neurosci Program Binghamton NY 13902 USA;

    SUNY Binghamton Binghamton Univ Dept Psychol Behav Neurosci Program Binghamton NY 13902 USA;

    SUNY Binghamton Binghamton Univ Dept Psychol Behav Neurosci Program Binghamton NY 13902 USA;

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  • 正文语种 eng
  • 中图分类 老年病学;
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