首页> 外文期刊>Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association >Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis
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Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis

机译:ALDH2和ADH1B多态性之间的关联,酒精饮用和胃癌:复制和调解分析

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Background Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADHIB; rs1229984, His47Arg) polymorphisms have a strong impact on carcinogenic acetaldehyde accumulation after alcohol drinking. To date, however, evidence for a significant ALDH2-alcohol drinking interaction and a mediation effect of ALDH2IADHIB through alcohol drinking on gastric cancer have remained unclear. We conducted two case-control studies to validate the interaction and to estimate the mediation effect on gastric cancer.
机译:背景醛脱氢酶2(ALDH2; RS671,GLU504LY)和醇脱氢酶1B(ADHIB; RS1229984,HIS47ARG)多态性对酒精饮用后的致癌丙醛积累产生强烈影响。 然而,迄今为止,有关重要的Aldh2-酒精饮用相互作用和Aldh2iadibih含量通过酒精饮料对胃癌饮用的证据仍然不清楚。 我们进行了两项案例对照研究,以验证互动,估计对胃癌的调解作用。

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