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首页> 外文期刊>Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function >Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies
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Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies

机译：在白细胞介素-1B和慢性牙周炎中的RS1143634多态性之间的关联：由54例/对照研究组成的META分析结果

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摘要

Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5.2 statistical software with Odds Ratio (OR) calculation and Funnel plot (P 0.05) to heterogeneity and the Comprehensive Meta analysis version 3.3.070 to assessment publication bias by Egger's and Begg's tests. In overall, 54 case/control studies composed the meta-analysis. T allele was significantly associated with patients case (OR = 1.35, 95% CI: 1.24, 1.48, P 0.00001) in the overall analysis. The stratified evaluation showed the rs1143634 polymorphism had significant association with disease in Caucasian, Asian and mixed population was excepted in African ethnicity (P 0.05). No publication bias was found in allelic evaluation. This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population.
机译：几个因素涉及通过细胞因子与宿主响应的牙周炎以及多态性在细胞因子基因中的影响，然而结果保持矛盾。该研究旨在评估白细胞介素-1B基因，细胞因子基因的Rs1143634多态性，以及在族种群中进行荟萃分析的慢性牙周炎的风险。文学中的审查是在2017年6月之前发布的研究中出版的研究。通过两种校准的调查员进行数据提取，通过审查经理版本5.2统计软件进行差异率（或）计算和漏斗的计算。绘图（P＆ 0.05）到异质性和综合元分析3.3.070，通过Egger和Begg的测试评估出版物偏见。总体而言，54例/对照研究组成了Meta分析。在整体分析中，患者与患者病例（或= 1.35,95％CI：1.24,1.48，P <0.00001）显着相关。分层评价显示，RS1143634多态性与高加索人中的疾病有重大关联，亚洲和混合人群在非洲种族（P＆GT; 0.05）中除外。在等特性评估中没有发现出版物偏见。该荟萃分析在9376名参与者中，有54例/对照研究的揭示rs1143634多态性与慢性牙周炎的风险相关，慢性牙周炎在整体分析以及白种人和亚洲种族和混合人口中。

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