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首页> 外文期刊>Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function >Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population
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Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population

机译：在哥伦比亚人群中，美国原住民祖先，adipor2，MTNR1B，GCK，TCF7L2和FTO基因的常见变体与血糖性状

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Insulin resistance and defects in other related glycemic traits are common findings in the context of Metabolic Syndrome. Although genetic factors are clearly implied in susceptibility, and some gene variants have been identified mainly in populations of European ancestry, little is known about this aspect in admixed populations. The association of insulin resistance, beta-cell function, fasting insulin and glucose levels with 48 gene variants, previously related to metabolic syndrome components, and with the ancestral genetic composition, estimated on 50 ancestry informative markers, was evaluated in 417 individuals from the Colombian admixed population. The Native American genetic ancestry was associated with a low beta-cell function (odds ratio (OR) of 1.73 and 95% confidence interval (95% CI) of 1.07-2.81, p = 0.026). Significant genotypic associations were obtained (q-value 0.05) for gene variants in ACE (rs4340; OR (95% CI): 2.79 (1.58-4.91), insulin resistance; mean difference (95% CI): 0.273 (0.141; 0.406), fasting insulin), ADIPOR2 (rs11061971; OR (95% CI): 0.14 (0.04-0.48), low beta-cell function), MTNRIB (rs10830963; mean difference (95% CD: 0.032 (0.013; 0.051), fasting glucose) and GCK (rs4607517; mean difference (95% CI): 0.038 (0.020;0.056) and rs1799884; mean difference (95% CI): 0.027 (0.013-0.041), fasting glucose). Also the well-known gene variants rs7903146 in TCF7L2, and rs17817449 in FTO, were nominally associated with hyperglycemia (rs7903146), as well as with higher fasting insulin levels (rs17817449). Our findings indicate that gene variants in ACE, ADIPOR2, MTNRIB, GCK, TCF7L2 and FTO, are associated with glycemic traits in the admixed Colombian population, while a higher Native American genetic component is related to lower beta-cell function.
机译：在代谢综合征的背景下，其他相关血糖性状的胰岛素抵抗和缺陷是常见的发现。虽然遗传因素明确暗示易感性，但是一些基因变体主要鉴定在欧洲血统的群体中，但对混合群体的这一方面几乎是众所周知的。胰岛素抵抗，β细胞功能，禁食胰岛素和葡萄糖水平的结合，以前与代谢综合征成分和祖先遗传组合物相关的48个基因变体，估计在50名祖先的信息标志物中，评估了来自哥伦比亚的417名祖先的信息标志物混合人口。美洲原住民遗传血汁与低β细胞功能（1.73和95％置信区间（95％CI）为1.07-2.81，P = 0.026）的β细胞功能有关。获得了重要的基因型缔酶（Q值<0.05），用于ACE中的基因变体（RS4340;或（95％CI）：2.79（1.58-4.91），胰岛素抵抗;平均差异（95％CI）：0.273（0.141; 0.406），禁食胰岛素），adipor2（Rs11061971;或（95％CI）：0.14（0.04-0.48），低β细胞功能），MTNRIB（RS10830963;平均差异（95％CD：0.032（0.013），空腹葡萄糖）和GCK（RS4607517;平均差异（95％CI）：0.038（0.020; 0.056）和RS1799884;平均差异（95％CI）：0.027（0.013-0.041），空腹葡萄糖。也是众所周知的基因TCF7L2中的变体RS7903146和FTO的RS17817449名义上与高血糖（RS7903146）相关，以及较高的空腹胰岛素水平（RS17817449）。我们的研究结果表明ACE，Adipor2，MTNRIB，GCK，TCF7L2和FTO中的基因变体，与混合哥伦比亚人群中的血糖性状有关，而较高的美洲美洲遗传组分与低β细胞功能有关。

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