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Potential for peritoneal cancer cell seeding in endoscopic full-thickness resection for early gastric cancer

机译：用于早期胃癌内镜全厚切除腹膜癌细胞播种的潜力

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摘要

Background and Aims During endoscopic full-thickness resection (EFTR) for cancers, whether exposure of the lumen to the abdominal cavity during the procedure is acceptable is controversial because of the potential risk of tumor cell seeding. To assess the possibility of transplantation as a result of contact with tumor cells during the procedure, we prospectively investigated the ability of cancer cells to be detached by touching the tumor surface. Methods In 48 patients with a single early gastric cancer resected by endoscopic submucosal dissection, stamp cytology was performed by touching the surface of the specimens to glass slides. Samples were obtained from cancerous and noncancerous areas, constituting the study and control groups, respectively. The detection rate of malignant class IV or V (C-IV/C-V) samples was investigated with Papanicolaou staining. The rate of CD44v9-positive cases, a cancer stem cell marker, was assessed in C-IV/C-V samples with immunohistochemical staining. Results Detection rates of C-IV/C-V samples in the cancerous group (53/192 slides, 27.6%) differed significantly from those of the C-IV/C-V samples in the noncancerous group (0/96 slides, 0%). Among the 53 slides of C-IV/C-V samples in the cancerous group, CD44v9 cells were expressed in 18 slides (34.0%). Conclusions These data suggest that cancer cells, including cancer stem cells, in early gastric cancers are easily detached via contact with the tumor surface. In EFTR, a nonexposure approach is recommended to avoid the risk?of iatrogenic cancer cell seeding via contact with and transplantation of cancer cells. Graphical Abstract Display Omitted
机译：背景和目的在内窥镜全厚度切除（EFTR）期间用于癌症，在该程序期间是否在手术过程中暴露于腹腔，是由于肿瘤细胞播种的潜在风险是有争议的。为了评估在该程序期间与肿瘤细胞接触的导致移植的可能性，我们前瞻性地研究了通过触摸肿瘤表面来分离的癌细胞的能力。方法在48例患有内窥镜粘膜粘膜粘膜下切除的早期胃癌的患者中，通过将标本的表面接触到玻璃载玻片来进行印刷细胞学。样品分别从癌症和非癌症区域获得，分别构成研究和对照组。利用帕帕内尼乳杆菌染色研究了恶性IV类或V（C-IV / C-V）样品的检出率。在具有免疫组织化学染色的C-IV / C-V样品中评估CD44V9阳性患者癌症干细胞标志物的速率。结果癌癌（53/192载玻片，27.6％）中C-IV / C-V样品的检测率显着不同于非癌症中的C-IV / C-V样品（0/96载玻片，0％）。在癌癌中的53个载玻片中，CD44V9细胞以18次载玻片（34.0％）表示。结论这些数据表明，在早期胃癌中，包括癌症干细胞，包括癌症干细胞的癌细胞易于通过与肿瘤表面接触脱离。在EFTR中，建议使用非缺陷方法来避免风险？通过接触和移植癌细胞接触的认可癌细胞播种。省略了图形抽象显示

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  • 来源
    《Gastrointestinal Endoscopy》 |2018年第2期|共7页
  • 作者

    Osamu Goto; Masayuki Shimoda; Motoki Sasaki; Yoshiyuki Kiguchi; Yutaka Mitsunaga; Teppei Akimoto; Yasutoshi Ochiai; Ai Fujimoto; Tadateru Maehata; Toshihiro Nishizawa; Hiroya Takeuchi; Yuko Kitagawa; Kaori Kameyama; Naohisa Yahagi;

  • 作者单位

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Department of Pathology Keio University School of Medicine;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

    Department of Surgery Keio University School of Medicine;

    Department of Surgery Keio University School of Medicine;

    Division of Diagnostic Pathology Keio University School of Medicine;

    Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio;

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  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
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  • 入库时间 2022-08-20 03:04:13

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