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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Radioimmunoscintigraphy with Tc-99m-labelled SM3 in differentiating malignant from benign adnexal masses.
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Radioimmunoscintigraphy with Tc-99m-labelled SM3 in differentiating malignant from benign adnexal masses.

机译：用Tc-99m标记的SM3进行放射免疫显像，以区分恶性和良性附件包块。

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Ultrasound scanning, serum CA125 and menopausal status have previously been combined in a risk of malignancy index for the differential diagnosis of adnexal masses. Although this approach has greater accuracy than either individual tests or clinical assessment, it has a significant false positive and false negative rate. Efforts have been directed at refining differential diagnosis and this study assessed the role of radioimmunoscintigraphy using the stripped mucin 3 (SM3) antibody that has a 17-fold greater uptake in malignant than benign ovarian tumours in vitro.Prospective study of patients with a pelvic mass using radioimmunoscintigraphy.Department of Nuclear Medicine of St Bartholomew's Hospital in collaboration with Cancer Network.A total of 93 patients with pelvic masses were recruited for this study of which 32 had ovarian cancer and 61 had benign lesions.Radioimmunoscintigraphy was performed with Tc-99m-labelled SM3 (600 MBq), anterior and posterior pelvis imaged at 10 minutes and at 4 and 24 hours and evaluated with change detection analysis and probability mapping.Sensitivity and specificity of radioimmunoscintigraphy for ovarian cancer.Radioimmunoscintigraphy had a sensitivity for ovarian cancer of 84% (27 true positive and 5 false negatives) and a specificity of 87% (53 true negatives and 8 false positives) giving a negative predictive value of 91%.These results suggest that radioimmunoscintigraphy could be used to reduce the number of false positive findings in a strategy to refine differential diagnosis of the pelvic mass.
机译：超声扫描，血清CA125和更年期状态先前已合并恶性指数的风险，可用于附件包块的鉴别诊断。尽管此方法比单独的测试或临床评估具有更高的准确性，但它具有明显的假阳性和假阴性率。一直致力于改善鉴别诊断，这项研究使用在体外对恶性肿瘤的摄取比在卵巢良性肿瘤中高17倍的剥离粘蛋白3（SM3）抗体，评估了放射免疫闪烁成像的作用。圣巴塞洛缪医院核医学科与癌症网络合作。本研究共招募93例盆腔肿块患者，其中32例患有卵巢癌，61例患有良性病变.Tc-99m-标记为SM3（600 MBq）的骨盆，前后骨盆分别在10分钟，4和24小时成像，并通过变化检测分析和概率图进行评估。放射免疫闪烁成像对卵巢癌的敏感性和特异性放射免疫闪烁成像对卵巢癌的敏感性为84％ （27个真实阳性和5个假阴性）和87％的特异性（53个真实阴性和8个假阳性）给出91％的阴性预测值。这些结果表明，放射免疫显像技术可用于减少盆腔肿块鉴别诊断的策略中减少假阳性结果的数量。

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