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首页> 外文期刊>General and comparative endocrinology >The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide (Reprinted from General and Comparative Endocrinology, vol 195, pg 1-8)
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The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide (Reprinted from General and Comparative Endocrinology, vol 195, pg 1-8)

机译：三种进化和序列相关神经肽的分布和生理效应rhodnius volimimus：脂质激素，Corazonin和脂肪激素/ corazonin相关肽（转载于一般和比较内分泌，Vol 195，PG 1-8）

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We have examined the distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus. These neuropeptides, adipokinetic hormone (RhoprAKH), corazonin (CRZ) and adipokinetic hormone/corazonin-related peptide (RhoprACP) are present in distinct, non-overlapping neuronal subsets in the central nervous system (CNS), as determined by immunohistochemistry. Corazonin-like immunoreactive cell bodies are present in the brain and ventral nerve cord, whereas ACP-like immunoreactive cell bodies are only present in the brain, and AKH-like immunoreactive cell bodies only present in the corpus cardiacum (CC). The immunoreactivity to ACP, CRZ and AKH in R. prolixus suggests that ACP and CRZ are released within the CNS, and that CRZ and AKH are released as neurohormones from the CC. Injection of RhoprAKH into adult males elevated haemolymph lipid levels, but injection of CRZ or RhoprACP failed to have any effect on haemolymph lipid levels. Corazonin stimulated an increase in heart-beat frequency in vitro, but RhoprAKH and RhoprACP failed to do so. Thus, although all three neuropeptides share sequence similarity, the AKH and CRZ receptors only respond to their own ligand. (C) 2014 Elsevier Inc. All rights reserved.
机译：我们研究了三种进化和序列相关神经肽的分布和生理效应rhodnius咯咯笑。这些神经肽，促进激素（rhoRKAKH），Corazonin（CRZ）和促进激素/ Corazonin相关肽（rhOlacp）存在于中枢神经系统（CNS）中的不同的非重叠神经元亚群中，如免疫组织化学所确定的。类似于脑和腹神经帘线存在的冠状素免疫反应性细胞体，而ACP样免疫反应性细胞体仅存在于脑中，并且仅存在于Corpiacum（CC）中仅存在的AkH样免疫反应性细胞体。 R.Croxus的ACP，CRZ和AKH的免疫反应性表明，ACP和CRZ在CNS内释放，CRZ和AKH从CC中作为神经异源释放。将rhoRkhh注射到成年雄性升高的毒液脂肪水平，但注射CRZ或rhOlacp未对血小差水平没有任何影响。 Corazonin刺激了体外心脏搏动频率的增加，但rhoRkhh和rhoprocp未能这样做。因此，尽管所有三种神经肽共享序列相似性，但AKH和CRZ受体仅对自己的配体响应。 （c）2014年elsevier Inc.保留所有权利。

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