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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats
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Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats

机译：丁仙药丸在五苯甲酸四虫唑类老鼠的抗惊厥作用

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摘要

Dingxian pill has been used as an antiepilepsy agent in China from ancient to modern times, of which the concrete pharmacological characterization and the underlying molecular mechanism remain unclear. The present study was undertaken to investigate them by animal behavior, electroencephalogram (EEG), Morris water maze, immunohistochemistry, transcriptomics, and real-time PCR. In our results, the treatment of Dingxian pill dose-dependently inhibited PTZ-induced seizure-like behavior and reduced the seizure grades, LFP power spectral density, and brain wave of the epileptiform EEG component induced by PTZ. In Morris water maze tests, the learning and memory ability of kindled epileptic rats could be attenuated more efficiently by Dingxian pill. For the immediate early gene c-fos, the expression was reduced after Dingxian pill treatment, and the difference was significant between the treatment and the model group. Through the transcriptome analysis of the gene expression in hippocampus, Egr3, Nrg, Arc, and Ptgs2, closely related to epilepsy, had been proved to be downregulated by application of Dingxian pill. All of the results not only highlight the antiepileptic effects of Dingxian pill and its molecular mechanism, but also provide a modern validity theory for the clinical application of traditional Chinese medicine (TCM).
机译：鼎县药丸已被用作中国的抗癫痫药，从古代到近代，其中具体的药理学表征和潜在的分子机制仍然尚不清楚。本研究进行了通过动物行为，脑电图（EEG），莫里斯水迷宫，免疫组织化学，转录组和实时PCR来研究它们。在我们的结果中，治疗垂氏丸剂量依赖性抑制PTZ诱导的癫痫发作的行为，并降低了PTZ诱导的癫痫型脑电图组分的癫痫率等级，LFP功率谱密度和脑波。在莫里斯水迷宫测试中，点燃癫痫大鼠的学习和记忆能力可以通过丁仙药更有效地衰减。对于立即早期基因C-FOS，丁仙丸处理后表达减少，差异在治疗和模型组之间具有显着性。通过对海马的基因表达的转录体组，EGR3，NRG，弧和PTGS2与癫痫密切相关，已被证明通过应用丁仙药丸下调。所有结果不仅突出了丁仙药丸的抗癫痫作用及其分子机制，而且还为中药（TCM）的临床应用提供了现代有效性理论。

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