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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10
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Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10

机译：中药，Zishen Yutai丸，改善受控卵巢过度刺激诱导的早熟子宫内膜成熟，通过Hoxa10的上调提高子宫接受

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摘要

Controlled ovarian hyperstimulation (COH) is widely used in assisted reproductive technology (ART), but it often leads to precocious maturation of the endometrium such that it impairs embryonic implantation and limits pregnancy rates. Previous studies have shown the traditional Chinese medicine, the Zishen Yutai pill (ZYP), to be effective in treatment of threatened as well as recurrent miscarriages, and it can improve embryonic implantation rates in patients undergoing IVF treatment. In the present study, the ZYP has been found to ameliorate precocious endometrial maturation in a mouse model of different COH. Molecular evaluations, real-time PCR, relative RT-PCR, Western blotting, and immunohistochemistry have indicated that the ZYP increased the expression of HOXA10, an important marker of uterine receptivity. Elevation of HOXA10 led to further upregulation of its target gene, integrin.. 3, and downregulation of EMX2, two additional markers of uterine receptivity. In this way, the ZYP may mitigate COH-induced precocious maturation of the endometrium and improve uterine receptivity by upregulating HOXA10.
机译：受控卵巢过度刺激（COH）广泛用于辅助生殖技术（艺术品），但它通常导致子宫内膜的早熟成熟，使得它损害胚胎植入并限制妊娠率。以往的研究表明，中医，Zishen Yutai丸（Zyp），有效地治疗受威胁和复发性流产，并且可以改善接受IVF治疗患者的胚胎植入率。在本研究中，已发现Zyp在不同COH的小鼠模型中改善了早熟的子宫内膜成熟。分子评价，实时PCR，相对RT-PCR，Western印迹和免疫组化表明Zyp增加了Hoxa10的表达，是子宫接受性的重要标志物。 Hoxa10的升高导致其靶基因进一步上调，整合素.. 3，eMX2的下调，两种子宫接受性标记。以这种方式，ZyP可以减轻Coh诱导的子宫内膜的早熟成熟，并通过上调Hoxa10来改善子宫接受。

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    Gao Qi; Han Lu; Li Xiumei; Cai Xia;

  • 作者单位

    Tradit Chinese Med Hosp Xinjiang Uygur Autonomous Dept Gynecol Urumqi 830000 Xinjiang Peoples R;

    Tradit Chinese Med Hosp Xinjiang Uygur Autonomous Dept Gynecol Urumqi 830000 Xinjiang Peoples R;

    Xinjiang Med Univ Dept Morphol Ctr Urumqi 830000 Xinjiang Peoples R China;

    Xinjiang Med Univ Reprod Ctr Teaching Hosp 1 Urumqi 830000 Xinjiang Peoples R China;

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  • 正文语种 eng
  • 中图分类 临床医学;
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