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Advances in immunotherapy for pediatric acute myeloid leukemia

机译:小儿急性髓性白血病免疫疗法的进展

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Introduction: Achieving better disease control in patients diagnosed with acute myeloid leukemia (AML) has proven challenging. Overall survival has been impacted by addressing treatment related mortality with focused supportive care measures. Despite this improvement, it remains difficult to induce durable leukemia remissions despite aggressive chemotherapeutic regimens. The addition of hematopoietic stem cell transplants (HSCT) has allowed further treatment intensification and provided the benefit of graft-versus-leukemia (GVL) effect. However, HSCT carries the risk of transplant related morbidities, particularly GVHD, and anti-tumor responsiveness is still suboptimal. Thus, there is a need for alternate therapies. Immunotherapy has the potential to address this need.
机译:介绍:在诊断患有急性髓性白血病(AML)的患者中实现更好的疾病控制已被证明有挑战性。 通过以重点支持护理措施解决有关的死亡率,对整体生存产生了影响。 尽管有这种改善,但尽管有侵略性的化学治疗方案,但它仍然难以诱导耐用的白血病保留。 添加造血干细胞移植(HSCT)允许进一步治疗强化,并提供了接枝 - 与白血病(GVL)效应的益处。 然而,HSCT携带移植相关病症的风险,特别是GVHD,抗肿瘤反应性仍然是次优。 因此,需要替代疗法。 免疫疗法有可能解决这种需求。

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