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Induction of cellular and molecular Immunomodulatory pathways by vitamin E and vitamin C

机译：维生素E和维生素C诱导细胞和分子免疫调节途径

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Introduction: Vitamins E and C are well known small molecules that have been used to maintain health for decades. Recent studies of the cellular and molecular pathways leading to immunomodulation by these molecules have been of interest, as have their anti-oxidant properties and signal transduction pathways for curing or improving infectious diseases and cancer.Areas covered: Herein, the authors provide a definition and the structural classification of vitamins E and C and how these molecules influence cellular function. The studies include in vitro, ex vivo and in vivo studies in animal models as well as clinical trials. The authors give particular focus to the scientifically factual and putative roles of these molecules in innate and adaptive immunomodulation and prevention or cure of diseases.Expert opinion: The antioxidant properties of vitamins E and C are well studied. However, whether there is a link between their antioxidant and immunomodulation properties is unclear. In addition, there is a strong, albeit putative, prevailing notion that vitamin C can prevent or cure infectious diseases or cancer. Presently, while there is proven evidence that vitamin E possesses immunomodulatory properties that may play a positive role in disease outcomes, this evidence is less available for vitamin C.
机译：简介：维生素E和C是众所周知的小分子，用于维持数十年的健康。最近对由这些分子免疫调节的细胞和分子途径的研究具有感兴趣的，如它们的抗氧化性能和用于固化或改善传染病和癌症的信号转导途径。涵盖：本文，提交人提供了定义和维生素E和C的结构分类以及这些分子如何影响细胞功能。研究包括体外，例如动物模型的体内和体内研究以及临床试验。作者特别关注这些分子在先天和适应性免疫调节和预防或治愈疾病中的科学事实和推定作用.Pert意见：培养型e和c的抗氧化性能研究。然而，是否存在抗氧化剂和免疫调节性能之间的链接尚不清楚。此外，维生素C可以预防或治愈传染病或癌症的强大，忠告的巨大概括的观点。目前，虽然有证据表明维生素E具有可能在疾病结果中发挥阳性作用的免疫调节性质，但这种证据对维生素C不太可用。

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