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首页> 外文期刊>Expert opinion on biological therapy >Reprogramming T-cells for adoptive immunotherapy of ovarian cancer
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Reprogramming T-cells for adoptive immunotherapy of ovarian cancer

机译：重新编程卵巢癌继承免疫治疗的T细胞

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Introduction: Epithelial ovarian cancer (EOC) is the most common cause of death among gynecological malignancies. Despite surgical and pharmacological efforts to improve patients outcome, persistent and recurrent EOC remains an un-eradicable disease. Chimeric associated antigens (CAR) T cells are T lymphocytes expressing an engineered T cell receptor that activate the immune response after an MHC unrestricted recognition of specific antigens, including tumor associated antigens (TAAs). CART cells have been shown to be effective in the treatment of hematologic tumors even if frequently associated with potentially severe toxicity and high production costs. Areas covered: In this review, we will focus on preclinical and clinical studies evaluating CART activity in EOC in order to identify possible difficulties and advantages of their use in this particular setting. Expert Opinion: The pattern of diffusion within the peritoneal cavity, the tumor microenvironment and the high rate of TAAs make EOC a particularly interesting model for CART cells use. Data from preclinical studies indicate a potential activity of CARTs in EOC, but robust clinical data are still awaited. Further studies are needed to determine the best methods of administration and the most effective CAR type to treat EOC patients.
机译：简介：上皮卵巢癌（EOC）是妇科恶性肿瘤中最常见的死因。尽管手术和药理学努力改善患者的结果，但持续和复发的EOC仍然是一种无法剥夺的疾病。嵌合相关抗原（CAR）T细胞是表达工程化T细胞受体的T淋巴细胞，其在肿瘤相关抗原的MHC不受限制的识别后激活免疫应答，包括肿瘤相关抗原（TAAS）。即使经常与潜在严重的毒性和高生产成本经常相关，已经显示出血液学肿瘤的治疗方法是有效的。所涵盖的地区：在本综述中，我们将专注于评估EoC中的推车活动的临床前和临床研究，以确定其在这种特定环境中使用的可能困难和优势。专家意见：腹膜腔内的扩散模式，肿瘤微环境和TAA的高速率使得eoc成为购物车细胞的特别有趣的模型。来自临床前研究的数据表明EOC中推车的潜在活动，但仍然可以等待强大的临床资料。需要进一步的研究来确定最佳的给药方法和最有效的汽车类型治疗EOC患者。

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