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The effect of biological DMARDs on the risk of congestive heart failure in rheumatoid arthritis: a systematic review

机译：生物DMARDS对类风湿性关节炎充血性心力衰竭风险的影响：系统综述

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Introduction: A common cardiovascular manifestation in rheumatoid arthritis (RA) is congestive heart failure (CHF) in which inflammation is considered to play a pivotal role. Although anti-inflammatory therapy such as biological disease-modifying anti-rheumatic drugs (bDMARDs) have the potential of improving the cardiac function and reducing the risk of CHF, the published studies showed contrasting results. This review aims to systematically summarize and analyze literature regarding the effect of bDMARDs on the cardiac function and on the risk of CHF in RA. Areas covered: Observational cohort, randomized controlled trials and case-controlled studies were included. The systematic literature search was conducted in PubMed, Wiley/Embase, Cochrane, Web of Science and clinicaltrials.gov (up to 2017). Two authors assessed abstracts for inclusion and methodological quality was assessed by one reviewer. Expert opinion: RA patients have a clinically relevant increased risk of developing CHF needing further attention. However, we found a lack of high quality studies. Future studies should focus on distinguishing the effect of myocardial inflammation reduction versus antibody-specific myocardial cellular effects of bDMARDs to improve the understanding of the effects of bDMARDs in RA patients and the relation with the development of CHF.
机译：介绍：类风湿性关节炎（RA）中的常见心血管表现是充血性心力衰竭（CHF），其中炎症被认为发挥枢轴作用。虽然抗炎疗法如生物疾病改性抗风湿药物（BDMARDS）具有改善心脏功能的潜力，但发表的研究表明对比结果。该审查旨在系统地概述和分析文献，了解BDMARD对心脏功能以及雷中CHF风险的影响。包括：包括观察队，随机对照试验和案例控制研究。系统文献搜索是在PubMed，Wiley / Embase，Cochrane，Science和Clinicaltrials.gov（截止日期为2017年）进行的。一位评价审查员评估了两位作者评估了摘要和方法质量的摘要。专家意见：RA患者在临床相关的增加的风险增加的风险，需要进一步关注CHF。但是，我们发现缺乏高质量的研究。未来的研究应侧重于区分心肌炎炎症的影响与BDMARDS的抗体特异性心肌细胞作用与抗体特异性心肌细胞效应的影响改善了解对患者的BDMARDS的影响以及与CHF发育的关系。

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