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首页> 外文期刊>Expert opinion on biological therapy >Practical considerations for chimeric antigen receptor design and delivery
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Practical considerations for chimeric antigen receptor design and delivery

机译：嵌合抗原受体设计和交付的实践考虑

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Introduction: The development of chimeric antigen receptor (CAR)-modified immune cells has become a highly active field of research since the introduction of this approach in 1989. New ideas are constantly being proposed and tested, resulting in CARs that are more effective and specialized.Areas covered: Many aspects of CAR design and administration can be varied in order to achieve the best possible outcomes; optimization of this therapeutic schema is an active area of research. Here, the authors summarize the work that has been carried out thus far to assess different adaptations for each portion of the CAR itself. They also discuss the various methods used for CAR transgene transfer into effector cells.Expert opinion: While the field has made significant advancements in terms of expansion and testing of the variations available for CAR therapy, it remains difficult to ascertain which options are truly superior and under what conditions. Continued research in this area, as well as in aspects such as improving the safety profile and the anti-tumor potency of CARs, will be required to bring this therapy from early-phase clinical trials to standard of care as an effective treatment for a broad range of tumor types.
机译：引言：嵌合抗原受体（汽车）制定的免疫细胞已成为1989年引入这种方法的高度活跃的研究领域。不断提出和测试新的想法，导致汽车更有效和专业化。areas覆盖：可以改变汽车设计和管理的许多方面，以达到最佳结果;这种治疗模式的优化是一个活跃的研究领域。在这里，作者总结了迄今为止已经进行的工作，以评估汽车本身各个部分的不同调整。他们还讨论了用于汽车转基因转移到效应细胞的各种方法.Pert意见：虽然该领域在扩大和测试可用于汽车治疗的变化方面取得了重大进步，但仍然难以确定哪种选择真正优越的选择在什么条件下。在这一领域的持续研究以及改善汽车的安全性和汽车的反肿瘤效力等方面，将需要从早期临床试验到护理标准作为宽阔的疗法肿瘤类型的范围。

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