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首页> 外文期刊>Genetic Resources and Crop Evolution >Exhausted model selection for multitrait mapping QTL: application to barley (Hordeum vulgareL.) dataset
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Exhausted model selection for multitrait mapping QTL: application to barley (Hordeum vulgareL.) dataset

机译：MultiTrait Muthit Mapping QTL的耗尽模型选择：在大麦（Hordeum Wargarel。）数据集

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摘要

In this study, a QTL mapping method combining multiple traits is proposed. The key feature of the new method is that it tests all possible traits and chooses those affected traits in the model for a specific QTL, whereas these "working" traits may be different for different QTL. The BIC model selection criteria was used to choose the best model and to ascertain the "working" traits; then the "working" traits were combined together to detect QTL affecting these traits, by which it can boost QTL signals and increase statistical power. The new method has been applied to Barley dataset, which contains eight traits. The results showed that sometimes a QTL might affect more than one trait but not always affected all traits; the QTL detection power with new method was increased and 4 more QTLs were detected compared with single-trait method; generally, - logP values were much higher than those by single-trait analysis, but they were highly correlated, confirmed the unbiaseness of the new multitrait method. These results suggest that the developed multitrait method is effective for QTL mapping. The computational program is written in Fortran language for convenience to use, which is available on request.
机译：在该研究中，提出了一种组合多个特征的QTL映射方法。新方法的关键特征是它测试了所有可能的特征，并选择模型中的受影响的特征为特定QTL，而这些“工作”特征可以针对不同的QTL不同。 BIC模型选择标准用于选择最佳模型，并确定“工作”特征;然后将“工作”特征组合在一起以检测影响这些特征的QTL，通过该QTL可以提高QTL信号并增加统计功率。新方法已应用于麦基数据集，其中包含八个特征。结果表明，有时QTL可能会影响多于一个特质，但并非总是影响所有特征; QTL检测功率增加了新方法，与单个特征法相比，检测到4个QTL。通常， - LOMP值远高于单个特征分析的值，但它们具有高度相关性，确认了新的多应来方法的无偏见。这些结果表明，开发的多址法对QTL映射有效。为方便使用，计算程序以Fortran语言编写，可根据要求提供。

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  • 作者

    Ye Jinhua; Yang Hao; Yuan Yingbo; An Zenglong; Fang Ming; Wang Zhiyong; Jiang Dan;

  • 作者单位

    Heilongjiang Bayi Agr Univ Coll Sci Daqing 163319 Peoples R China;

    Jimei Univ Fisheries Coll Minist Agr &

    Rural Affairs Key Lab Hlth Mariculture East China Sea Xiamen 361021 Fujian Peoples R China;

    Jimei Univ Fisheries Coll Minist Agr &

    Rural Affairs Key Lab Hlth Mariculture East China Sea Xiamen 361021 Fujian Peoples R China;

    Heilongjiang Bayi Agr Univ Coll Econ &

    Management Daqing 163319 Peoples R China;

    Jimei Univ Fisheries Coll Minist Agr &

    Rural Affairs Key Lab Hlth Mariculture East China Sea Xiamen 361021 Fujian Peoples R China;

    Jimei Univ Fisheries Coll Minist Agr &

    Rural Affairs Key Lab Hlth Mariculture East China Sea Xiamen 361021 Fujian Peoples R China;

    Jimei Univ Fisheries Coll Minist Agr &

    Rural Affairs Key Lab Hlth Mariculture East China Sea Xiamen 361021 Fujian Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 农业生物学;
  • 关键词

    Multitrait; Barley; Qtlmapping; Trait-specific QTL;

    机译：MultiTrait;大麦;qtlmapping;特定特定的QTL;

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