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首页> 外文期刊>Geburtshilfe und Frauenheilkunde >Zika Virus and Pregnancy: Association between Acute Infection and Microcephaly in Newborns in the State of Rio de Janeiro, Brazil
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Zika Virus and Pregnancy: Association between Acute Infection and Microcephaly in Newborns in the State of Rio de Janeiro, Brazil

机译：Zika病毒与妊娠：巴西里约热内卢新生儿急性感染与微骨折之间的关联

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Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with symptoms occurring between 2015 and 2016 suggestive of acute ZIKV infection was carried out, with confirmation of infection done by blood or urine RT-PCR. The relative proportions of categorical variables were calculated for two distinct groups: pregnant women whose newborns had microcephaly and pregnant women who gave birth to infants without microcephaly. Confidence intervals with a 95% level of agreement were estimated for the relative ratios. Results A total of 1609 pregnant women with a mean age of 26.4 +/- 6.5 years were evaluated. As regards the time of acute infection, 19.6% (316) of cases occurred in the first trimester of pregnancy. Nineteen (76%) of the 25 cases with microcephaly (1.5%) were associated with an infection contracted in the first trimester of pregnancy (p < 0.001, OR = 13.7, 95% CI: 5.6 - 37.7). 48% (12/25) of the newborns with microcephaly had a birth weight of < 2500 grams, while only 7% (116/1597) of the group of newborns without microcephaly had a similarly low birth weight (p < 0.001, OR = 11.7, 95% CI: 5.2 - 26.2). Logistic regression showed that a birth weight of < 2500 g (OR = 12.54) and ZIKV infection in the first trimester of pregnancy (OR = 14.05) were associated with microcephaly (area under ROC curve = 0.86). Conclusion Acute ZIKV infection in the first trimester of pregnancy and low birth weight are associated with microcephaly.
机译：介绍该研究的目的是评估在巴西里约热内卢州的孕妇中微微畸形和急性感染与Zika病毒（ZIKV）的关联。通过实验室检测确认感染。材料与方法对2015年至2016年患者症状的横断面回顾性研究进行了急性ZIKV感染的暗示性，并确认血液或尿液RT-PCR进行的感染。分类变量的相对比例计算出两种不同的群体：新生儿有孕妇的孕妇，患有没有微微术的婴儿生育婴儿。估计相对比率为95％协议水平的置信区间。结果评估了1609名孕妇26.4 +/- 6.5岁的孕妇。关于急性感染的时间，19.6％（316）例妊娠期妊娠期患者。 MicroCephaly（1.5％）的25例25例中的19例（76％）与妊娠第一个三个月（P <0.001，或= 13.7,95％CI：5.6 - 37.7）相关的感染有关。 48％（12/25）新生儿的微肺的出生体重<2500克，而没有微微畸形的新生儿组只有7％（116/1597）的出生体重同样低（P <0.001，或= 11.7,95％CI：5.2 - 26.2）。 Logistic回归显示，在妊娠（OR = 14.05）的妊娠第一个三个月（或= 14.05）中的出生体重<2500克（或= 12.54）和ZIKV感染与微微术（ROC曲线下的面积= 0.86）有关。结论妊娠第一个妊娠晚期急性ZIKV感染与微微畸形有关。

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