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首页> 外文期刊>Geburtshilfe und Frauenheilkunde >5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy
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5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy

机译：5年的三级中心血小板减少妊娠的经验：妊娠血小板减少症，特发性血小板减少紫癜和怀孕的高血压障碍

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Aim To evaluate thrombocytopenic pregnancies including gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), and hypertensive disorders of pregnancy (HDP). Materials and Methods We evaluated the pregnancy outcomes and laboratory findings of 385 patients diagnosed with GT, ITP, or HDP whose thrombocyte levels were < 150 000/mu L. Results GT, ITP, and HDP were the final diagnoses in 315 (81.8%), 35 (9.1%), and 35 (9.1%) cases, respectively. Patients diagnosed during the 1st trimester and diagnosed with ITP had significantly lower minimal platelet counts during the antenatal period and prior to delivery (p < 0.001; p < 0.001; p < 0.001; p < 0.001). Transfusion of any kind of blood product was given in 9.9% (n = 38) of all cases. Twelve patients had methylprednisolone and/or intravenous immunoglobulin treatments during the antenatal period. All patients who had undergone medical treatment were also found to have ITP. Four out of 385 patients underwent hysterectomy post partum due to refractory hemorrhage. Analysis of newborn platelet levels showed no statistical differences between any of the groups. Despite the lack of statistical significance, the rate of thrombocytopenia in newborns was 50% in patients with severe thrombocytopenia, while rates were 25.6 and 18.1% in patients with moderate and mild thrombocytopenia, respectively. Conclusion Thrombocytopenic pregnancies must be carefully evaluated with regard to the severity of thrombocytopenia, gestational period at initial diagnosis, and etiology. In particular, patients with ITP must be evaluated carefully as these patients are more likely to require transfusions and have platelet counts < 50 x 10 (3) /mu l.
机译：目的评估血小板减薄妊娠（包括妊娠血小板减少症（GT），特发性血小板减少紫癜（ITP）和妊娠高血压病症（HDP）。材料和方法我们评估了患有GT，ITP或HDP的385名患者的妊娠结果和实验室发现，其血小板细胞水平<150 000 / mu L.结果GT，ITP和HDP是315（81.8％）的最终诊断，35（9.1％）和35例（9.1％）病例。在第一次三个月诊断患者并被诊断出ITP在产前期间和递送之前的血小板计数显着降低（P <0.001; P <0.001; P <0.001）。任何种类的血液产物的输血在所有病例的9.9％（n = 38）中给出。在产前期间，12名患者含有甲基己二龙和/或静脉内免疫球蛋白处理。还发现所有经过医疗治疗的患者都有ITP。由于耐火性出血，385名患者中有4例患者进行了宫颈切除术后。新生血小板水平的分析显示，任何组之间没有统计学差异。尽管缺乏统计学意义，但新生儿血小板减少率为50％的血小板减少症患者，分别为中度和轻度血小板减少的患者的速率为25.6％和18.1％。结论必须在血小板减少症的严重程度，初步诊断和病因中的严重程度方面仔细评估血小板减少妊娠。特别是，由于这些患者更有可能需要输血，并且具有血小板计数<50×10（3）/亩l，必须仔细评估ITP患者。

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