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首页> 外文期刊>Genes, brain, and behavior >Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice
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Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice

机译：临床前自愿饮用模型用于酒精禁止诱导的小鼠情感扰动

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Negative reinforcement is widely thought to play an important role in chronic alcohol-use disorders (AUDs), and high comorbidity between AUDs and affective disorders highlights the importance of investigating this relationship. Prominent models posit that repeated cycles of alcohol (ethanol, EtOH) exposure and withdrawal produce circuit adaptations in the central nervous system that drive a transition from positive- to negative reinforcement-based alcohol seeking. Evidence supporting this theory has accumulated in large part using forced EtOH administration models, such as chronic intragastric gavage and chronic vapor inhalation. However, recent studies utilizing simple voluntary EtOH delivery systems show that forced abstinence from EtOH intake administered by the animal itself can produce evolving and significant affective disturbances, particularly in female C57BL/6J mice. Here, we highlight these recent studies to support the idea that voluntary EtOH administration in mouse models, as well as a protracted abstinence period and less commonly used behavioral tasks, could unveil affective disturbances during abstinence that have remained elusive using high dosage forced EtOH administration paradigms.
机译：消极增强被广泛思考在慢性酒精使用障碍（AUDS）中发挥重要作用，患者与情感障碍之间的高合作率突出了调查这种关系的重要性。突出模型的反复循环醇（乙醇，EtOH）暴露和戒断产生电路适应的中枢神经系统，驱动从积极的加强对负强化的酒精寻求的过渡。支持该理论的证据使用强制EtOH给药模型在很大程度上积累，例如慢性胃肠饲养和慢性蒸气吸入。然而，利用简单的自愿EtOH递送系统的最近研究表明，由动物本身给药的EtOH摄入量的强制禁欲会产生不断发展和显着的情感紊乱，特别是在雌性C57BL / 6J小鼠中。在这里，我们突出了这些最近的研究，以支持在小鼠模型中的自愿ETOH管理以及长期的禁欲期和较少常用的行为任务的想法可以揭开禁欲期间的情感紊乱，这些禁止使用高剂量迫使ETOH管理范式难以捉摸。

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