...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes, brain, and behavior >Alcohol-dependent molecular adaptations of the NMDA receptor system
【24h】

Alcohol-dependent molecular adaptations of the NMDA receptor system

机译：NMDA受体系统的醇依赖性分子适应

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Phenotypes such as motivation to consume alcohol, goal-directed alcohol seeking and habit formation take part in mechanisms underlying heavy alcohol use. Learning and memory processes greatly contribute to the establishment and maintenance of these behavioral phenotypes. The N-methyl-d-aspartate receptor (NMDAR) is a driving force of synaptic plasticity, a key cellular hallmark of learning and memory. Here, we describe data in rodents and humans linking signaling molecules that center around the NMDARs, and behaviors associated with the development and/or maintenance of alcohol use disorder (AUD). Specifically, we show that enzymes that participate in the regulation of NMDAR function including Fyn kinase as well as signaling cascades downstream of NMDAR including calcium/calmodulin-dependent protein kinase II (CamKII), the -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and the mammalian target of rapamycin complex 1 (mTORC1) play a major role in mechanisms underlying alcohol drinking behaviors. Finally, we emphasize the brain region specificity of alcohol's actions on the above-mentioned signaling pathways and attempt to bridge the gap between the molecular signaling that drive learning and memory processes and alcohol-dependent behavioral phenotypes. Finally, we present data to suggest that genes related to NMDAR signaling may be AUD risk factors.
机译：诸如用于消耗酒精的动机，目标导向的酒精寻求和习惯形成的表型参与重质醇类使用的机制。学习和记忆流程大大有助于建立和维持这些行为表型。 N-甲基-D-天冬氨酸受体（NMDAR）是突触塑性的驱动力，学习和记忆的关键蜂窝标志。在这里，我们描述啮齿动物和人体中的数据，与围绕NMDARS围绕NMDAR的信号分子，以及与酒精使用障碍的开发和/或维持相关的行为（AUD）。具体地，我们表明，参与NMDAR功能的调节的酶包括Fyn激酶以及NMDAR下游的信号传导级联，包括钙/钙调蛋白依赖性蛋白激酶II（CAMKII）， - 氨基-3-羟基-5-甲基 - 4-异恶唑丙酸受体（AMPAR）和哺乳动物的雷帕霉素复合物1（MTORC1）的哺乳动物靶标在酒精饮酒行为的机制中起主要作用。最后，我们强调了醇地区对上述信令途径对醇的特异性，并试图弥合驱动学习和记忆过程和含醇类行为表型之间的分子信号之间的差距。最后，我们提出数据表明与NMDAR信号传导相关的基因可能是澳元危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号